1. Terc-53在衰老中的作用:Terc-53在小鼠中的过度表达在早期未发现发育缺陷或生理异常,但表现出与年龄相关的认知能力下降和寿命缩短,表明其参与正常的哺乳动物衰老过程。 2. 随后的机制研究发现透明质酸介导的运动受体(Hmmr)是Terc-53的主要效应器:Hmmr被确定为Terc-53的靶标,Terc-53介导Hmmr降解,导致受影响组织...
Terc-53 functions as a molecular scaffold bringing together Hmmr and Trim25, accelerating Hmmr's ubiquitination-mediated degradation, which consequently leads to neuroinflammation and cognition decline. Credit: Sipeng Wu, Yiqi Cai, Lixiao Zhang, Xiang Li, Xu Liu, Guangkeng Zhou, Hongdi Luo, Renjian...
结果表明,TERC-U2OS细胞的PD-L1 mRNA水平显著降低,证明TERC加速PD-L1 mRNA的降解。为了明确TERC是否直接与PD-L1 mRNA结合,作者用TERC探针对TERC水平是MG63细胞三倍的MCF7细胞进行RNA下拉实验,并用定量RT-PCR检测了沉淀物中PD-L1 mRNA表达水平。然而,PD-L1 ...
The VPS53/CCP17 FISH Probe Kit is designed to detect the human VPS53 gene located on chromosome band 17p13.3, along with the number of chromosome 17 copies per cell. Abnormalities in VPS53 – also known as HCCS1, PCH2E, hVps53L or pp13624 – have been observed in cancers including ...
hTERC基因在子宫颈上皮脱落细胞的表达及临床意义
Various Types of Cancer & Other Malignancies Diagnostic Kit The VPS53/CCP17 FISH Probe Kit is designed to detect the human VPS53 gene located on chromosome band 17p13.3, along with the number of chromosome 17 copies per cell. Abnormalities in VPS53 – also known as HCCS1, PCH2E, hVps...
1) TERC =Transportation Emergency Rescue Committee 运输紧急救援委员会例句>> 2) Emergency Relief Fund Committee 紧急救援基金委员会 例句>> 3) Ambulance Paramedic 紧急救援人员 例句>> 4) emergency rescue 紧急救援 1. Study on the development of emergency rescue function of the fire troop; 拓展...