Additionally, in the first 9 months of life, constipation must be differentiated from another FGIDs, infant dyschezia. Infants affected by this disorder present at least 10 min of straining and crying before successful or unsuccessful passage of soft stools, without any other health problems [3]...
The best compound tested (1e) also showed a uric acid inhibition of 60% at 1 h (10 mg/kg) in rats, beyond the excellent in vitro IC50 of 3.5 nM, comparable to febuxostat. The other derivatives also reached nanomolar IC50 values. A docking analysis shows the same interactions of the ...
In addition, Italy has displayed the lowest number of phase 1 clinical trials over the years compared to the other nations, while the UK has shown the highest number of registered phase 1 clinical studies. However, it is possible to observe fluctuations within each country from 2012 to 2021 ...
[4,5]. Moreover, functional alterations, biomechanical factors, aging, and metabolic disorders are predisposing factors increasing the risk of re-injury [1,2]. The process of tendinopathy involves collagen matrix and tenocytes [6,7]. In physiological conditions, collagen fibers are tightly ...