Finally, the infusion of TEMRA CD8 from KT recipients induces GVHD in 7 to 10 days with an infiltration of TEMRA in colon. Conclusion We demonstrate that TEMRA CD8 exhibit potent pathogenic function both in vitro when challenged with donor cells and in vivo resulting in an acute GVHD ...
研究人员在上述实验中借助了NEPA GENE品牌的NEPA21高效基因转染系统进行基因过表达和敲降,成功将3μg WT/Mutant-DTHD1过表达质粒和50 nM DTHD1 siRNA/NC siRNA分别电穿孔到5×106人原代CD8+ T细胞中,为实验的成功提供了重要助力。
接下来,Gate和他的同事分析了死于老年痴呆症的人的大脑。这揭示了CD8+ T细胞(可能是TEMRA细胞)存在于脑血管周围的血管周围空间,以及β淀粉样蛋白沉积的部位,正如以前报道的阿尔茨海默病中的T细胞。众所周知,CD8+ T细胞物理接触并切断神经突起,导致附近形成称为神经突起的球体结构——这是阿尔茨海默病的另一个标志。...
expansion of T effector memory CD45RA+ (TEMRA) CD4 T-cells, effector memory CD8 T-cells, CD21low B-cells and reduced memory switched B-cells. Addit... A Martínez-Feito,J Melero,S Mora-Díaz,... - 《Immunobiology》 被引量: 4发表: 2016年 Abnormalities of age-related T cell senescenc...
细胞毒性CD161-CD8+ TEMRA细胞参与系统性红斑狼疮的发病机制 系统性红斑狼疮(SLE)是一种典型的自身免疫性疾病,以免疫系统异常激活为特征,具有高度的细胞异质性,可导致多个器官和组织的慢性炎症和衰弱损害。SLE在临床上的发展、表征和严重程度具有较大差异性,病程难以预测。因此,准确识别SLE发病的遗传学和细胞型特异性...
综上所述,本研究在系统性红斑狼疮患者中发现了一种新的高活性的细胞毒性CD8+T细胞亚群CD161−CD8+TEMRA细胞,并进一步揭示了功能缺失的DTHD1促进CD161−CD8+ TEMRA细胞活化和细胞毒作用的分子基础,为SLE的临床诊断和治疗提供了新的机会。 NEPA21高效基因转染系统采用全新设计的四步法电转程序,配合专利的电压衰减...
In particular, terminally differentiated CD8+ effector memory CD45RA+ TEMRA cells and their subsets have characteristics of cellular senescence, accumulate in older individuals, and are increased in age-related chronic inflammatory diseases. In a detailed T-cell profiling among individuals over ...
Increase of CCR7- CD45RA+ CD8 T cells (T(EMRA)) in chronic graft-versus-host disease. Leukemia (2006) 20(3):545-7. doi:10.1038/sj.leu.2404079D'Asaro, M., Dieli, F., Caccamo, N., Musso, M., Porretto, F., Salerno, A. (2006) Increase of CCR72 CD45RA+ CD8 T cells (...
TEMRA CD8 T Cells Are Highly Cytopathic Cells That Escape From Costimulatory Based-Therapy.: Abstract# B1159Lung transplantation represents a highly successful therapy for patients with end-stage lung diseases. Nevertheless, compared with other types of solid-organ transplants, the surviv...
D'Asaro M, Dieli F, Caccamo N, Musso M, Porretto F, Salerno A. Increase of CCR7- CD45RA+ CD8 T cells (TEMRA) in chronic graft-versus-host disease. Leukemia 2006; 20:545-7.D’Asaro M, Dieli F, Caccamo N, Musso M, Porretto F, Salerno A. Increase of CCR7-CD45RA+ CD8 T ...