This study investigates different CD8 + T cell subsets usually associated with senescence, in cancer patients over 70years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the ...
Central memory CD8(+) T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression (vol 180, pg 7907, 2008) Progressive HIV disease has been associated with loss of memory T cell responses to Ag. To better characterize and quantify long-lived mem...
We demonstrate that CIK are terminally differentiated CD8 T cells that derive from proliferating CD3+CD56−CD8+ T cells. They express polyclonal T-cell receptor Vβ chains and have acquired CD56, NKG2D, and large granular lymphocyte morphology, but lack expression of most NK-specific activating ...
In aged mice treated with the senolytic navitoclax, in which we have previously shown a rejuvenated cardiac phenotype, CD8 effector memory cells are decreased, further indicating that alterations in T cell subpopulations are associated with cardiovascular ageing. Future studies are required to show ...
CD8-Positive T-LymphocytesK562 CellsImmunotherapyAntigens, DifferentiationCell DifferentiationCell ProliferationImmunity, CellularImmunologic MemoryCytokine-induced killer cells (CIK) are CD3CD56 T cells with natural killer (NK)−like cytotoxic activity used for the immunotherapy of tumors. We aimed to ...
T cell subpopulations were analyzed by flow cytometry. Furthermore, body composition, HOMA-IR, plasma tryptophan (Trp) metabolites, as well as cytokines and adipokines were determined. Using subgroup and covariance analyses, the influence of BMI on the parameters was evaluated. Moreover, correlation...