Bouquet formation is a nearly universal feature of this phase of meiosis and the movements of tethered telomeres help homologs find each other through physical alignment. Thus, telomere clustering per se may not be the goal of this movement. The details vary among different organisms. In fission ...
A mutation in the MEN factor Tem1 suppresses bub2Δ-induced sister-chromatid segregation [28]. It suggests that precocious activation of the MEN causes mitotic slippage, but the molecular mechanism responsible is largely unknown. Although securin degradation and sister-chromatid separation are normally...