Bouquet formation is a nearly universal feature of this phase of meiosis and the movements of tethered telomeres help homologs find each other through physical alignment. Thus, telomere clustering per se may not be the goal of this movement. The details vary among different organisms. In fission ...
We suspected that precocious MEN activation in nocodazole-treatedbub2Δcells causes activation of APC/C-Cdh1, leading to mitotic slippage. Indeed, a lack of Cdh1 markedly repressed sister-chromatid separation and nuclear division in nocodazole-treatedbub2Δcells (Figure2A, B). These observations clea...