There are many studies on the correlation of telomere length and aging rate. However, as the differences in the methods used in the studies and the scarcity of prospective studies; factors affecting telomere length are not really well understood. Some of the age related diseases may develop due...
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As NRF2 plays a crucial role in protecting cells from oxidative damage, an age-related decline in NRF2 function could be a key driving force behind telomere attrition. Here, we provide an overview of the molecular basis regulating the functional link between NRF2 and telomeres in aging and age-...
Cells are the basic unit of organismal structure and function, and mitochondria are the powerhouse and metabolic center of cells. Therefore, cellular senescence and mitochondrial dysfunction would result in tissue or organ degeneration and dysfunction followed by somatic aging through multiple pathways. ...
,TeloYears in the news New York Times 2011 interview with our founder, Elizabeth Blackburn, on her work in telomere biology and her decision to start the company that makes TeloYears.… March 30, 2017 Telomeres: Definition & Function
general trend of bulk telomere shortening as a function of donor age (Fig.4c). Telomere length assessment of individual chromosome arms confirmed the intrasample heterogeneity of chromosome arm-specific telomere length observed in HG002 and IMR90E6E7(Supplementary Fig.5b, cand Supplementary Data4)....
(A) Telomere length (kb) as a function of age in a large cohort of lymphocytes from healthy donors (150 donors, mean age 36 years, range 0.5–79 years) (red circles), in the father (blue triangle), in the mother (red square), and in the proband (purple cross). A linear ...
they all accompany at least one of the following medical issues: loss of immune function, pulmonary fibrosis, gastrointestinal disorders, liver cirrhosis, and neuropsychiatric conditions; affected persons could also have additional phenotypes of accelerated aging, such as diabetes, myocardial infarction, ha...
propagation of damaged cells by triggering their elimination via the immune system. The accumulation of senescent cells with aging reflects either an increase in the generation of these cells and/or a decrease in their clearance, which in turn aggravates the damage and contributes to aging [1]. ...
Telomere dysfunction impaired mesenchymal progenitor cell function, reduced the capacity of bone marrow stromal cells to maintain functional HSCs, and increased the expression of various cytokines, including granulocyte colony-stimulating factor (G-CSF), in the plasma of aging mice. Administration of G-...