“We have very deep insights into how telomerase works and how the components work together,” Susac said. “Each of these interactions could be a point to target, and possibly disrupt or enhance the function of telomerase. Precision will be very important; simply hitting telomerase with a hamm...
"We have very deep insights into how telomerase works and how the components work together," Susac said. "Each of these interactions could be a point to target, and possibly disrupt or enhance the function of telomerase. Precision will be very important; simply hittingtelomerasewith a hammer wo...
How relevant these observations are to human tumor biology cannot be ascertained at this time. Some tumors may utilize both telomerase and ALT activity [37,38], at least in part due to intratumoral heterogeneity. However, it is not known whether both telomere-lengthening mechanisms can ...
LARP7 and MePCE are mainly associated with the exS form in a step in which PARN is involved. However, how LARP7 and MePCE affect telomere homeostasis remains unclear. To evaluate the requirements of LARP7 and MePCE for telomerase maintenance, we knocked down LARP7 and MePCE in HeLa cells (...
Telomerase | Definition, Function & Clinical Uses from Chapter 10 / Lesson 15 26K Understand what telomerase is. Learn about the functions of telomerase. Discover how telomerase works and learn the structure of telomerase. Related to this QuestionWhy...
It has also been shown that PARP-1 modulates telomerase activity by altering poly-ADP-ribosylation of hTERT and/or the expression of telomerase associated protein1 (TEP1/TP1) subunit of telomerase holoenzyme [85]. All these observations show that having an understanding of how telomeric proteins ...
telomeres and telomerase Oncogene (2010) 29, 1561–1565; doi:10.1038/onc.2010.15 Elizabeth H Blackburn, Carol W Greider and Jack W Szostak were acknowledged with this year's Nobel Prize in Physiology or Medicine for their discoveries on how chromosomes are protected by telomeres and the enzyme ...
Next, we further studied how carboxylated SWNTs influenced cell proliferation, telomere structure and function. Cell growth suppression and DNA-damage response. The acute cytotoxic effects of carboxylated SWNTs in short-term cultures (3 and 6 days) were first assessed by using the XTT assay30 ...
Find out how to access preview-only content Telomerase Inhibition Methods in Molecular Biology™ Volume 405, 2007, pp 167-180 Screening of Telomerase Inhibitors Elke Kleideiter, Kamilla Piotrowska, Ulrich Klotz $49.95 / €39.95 / £34.95 * * Final gross prices may vary according to...
Find out how to access preview-only content Parasitology Research January 2012, Volume 110, Issue 1, pp 411-417 Date: 12 Jul 2011 Cloning and characterization of telomerase reverse transcriptase gene in Trichinella spiralis Yanan Cai, Yongxing Ai, Quan Zhao, Jianhua Li, Guilian Yang, ...