The length of the chromosome telomere has been associated with divisions and senescence of normal cells. Telomerase, the enzyme that adds nucleotides to the telomere, controls the telomere length. For instance, in stem cells and cancer cells, .Benjamin Yang...
binds six nucleotides and the second forms a pocket that buries the 3-terminal guanine base (Fig. 1) (13). Thus, hPOT1 appears to be "designed" to be a chr... L Ming,AJ Zaug,ER Podell,... 被引量: 267发表: 0年 Pharmaceutical regulation of telomerase and its clinical potential ...
Telomerase is a reverse transcriptase protein that is best known for its telomere maintenance functions in dividing cells. Telomeres serve as substrates for telomerase that adds repeated sequences of hexa-nucleotides to the ends of chromosomes, thus maintaining telomere length1,2. The catalytic core o...
Telomerase, a ribonucleoprotein enzyme complex that includes a cellular reverse transcriptase component that adds DNA to the ends of chromosomes, is reactivated or upregulated in the vast majority of human advanced malignancies but is not expressed in mo
binds six nucleotides and the second forms a pocket that buries the 3-terminal guanine base (Fig. 1) (13). Thus, hPOT1 appears to be "designed" to be a chr... L Ming,AJ Zaug,ER Podell,... 被引量: 267发表: 0年 Avian senescence: underlying mechanisms Candidate mechanisms for phys...
Telomerase is a specialized ribonucleoprotein polymerase that adds hexanucleotides (TTAGGG) onto human chromosomal ends. The expression of telomerase activ... WC Ku,AJ Cheng,TCV Wang - 《Biochemical & Biophysical Research Communications》 被引量: 383发表: 1997年 A Novel Tricomplex of BRCA1, Nmi,...
Telomerase is normally expressed primarily in development and its detection in over 90% of human cancers is considered the critical step to the immortality of neoplastic cells [31]. TERT mutations are located predominantly in the promoter, at positions 124 (C228T) and 146 bp (C250T) upstream ...
Progressive rounds of cell division result in a shortening of the telomeres by some 50-200 nucleotides per round. Almost all tumor cells have shortened telomeres, which are maintained at a constant length (Allshire et al., 1988; Harley et al., 1990; Harley et al., 1994) and are ...
1: Principle of the TeloTAGGG Telomerase PCR ELISAPLUS Step 1: Elongation/ Amplification: In the first step, telomerase adds telomeric repeats (TTAGGG) to the 3’-end of the biotin-labeled synthetic P1-TS-primer. These elongation products, as well as the Internal standard (IS) included in ...
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein Telomerase synthesizes telomeric DNA by copying a short template sequence within its telomerase RNA component. We delineated nucleotides and base-pairings ... J Lin,H Ly,...