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The role of AQP4-IgG and complement in inducing astrocytic death via C5b-9 activation and MAC formation in NMOSD has been well established. However, the mechanism by which they lead to TDP-43 proteinopathy remains unclear. A recent study suggests that the activation of the complement system ...
mRNA expression of proteins involved in the formation of the AP were also decreased, including the rapid component of the potassium repolarization current (KV11.1) and the depolarizing sodium current (NaV1.5). mRNA expression of the potassium current mainly responsible for the stabilization of the ...
At present, various theories exist regarding the cytotoxicity caused by the mislocalization of TDP-43 from the nucleus to the cytoplasm (Fig.3). The first theory postulates that neuronal exposure to specific stressors triggers the cytoplasmic mislocalization of TDP-43, leading to the formation of...
Fig. 1: Formation of the cytoplasmic condensates of TDP-43 carboxy terminal fragments (CTFs) in Neuro2a cells. a Primary structures and abbreviation of full-length TDP-43 (FL) and its carboxy-terminal fragments (CTFs): amino acids 220-414 (C220), 233-414 (C233), 243-414 (C243), 253...
mRNA expression of proteins involved in the formation of the AP were also decreased, including the rapid component of the potassium repolarization current (KV11.1) and the depolarizing sodium current (NaV1.5). mRNA expression of the potassium current mainly responsible for the stabilization of the ...
Medullary reticular formation MEPs: Motor evoked potentials Mol: Molecular layer of the dentate gyrus mTDP-43: Mouse TDP-43 mpi: Month post-injection MUAPs: Motor unit action potentials PK: Proteinase K pTDP-43: Phosphorylated TDP-43 pTDP-43-ir: pTDP-43-immunoreactive py: Decus...
[75]. Microglial NLRP3 inflammasomes can be activated by toxic ALS proteins, such as TDP-43 [70]. Here, we observed inflammasome formation by the presence of a perinuclear ASC speck structure that colocalised with NLRP3 protein in a small subset of ALS MDMi (3%) (Fig.4c). Pearson's ...
MEM minimal essential medium CFTR cystic fibrosis transmembrane conductance regulator WCL whole-cell lysate FA formic acid IP immunoprecipitate(s). 3 Please note that the JBC is not responsible for the long-term archiving and maintenance of this site or any other third party hosted site. ...
The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by ...