TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasmArticle Open access Published: 28 January 2025 Volume 8, article number 136, (2025) Cite this article Download PDF You have full access to this open access article ...
To quantify the concentration of p-tau and TDP-43 in the human brain homogenates, ELISA assays were carried out using commercially available kits (p-tau199 human ELISA Kit, ThermoFisher Scientific, #KHO0631 and human full-length (1-300aa.) TDP-43 ELISA Kit, Proteintech, #KE00005), accordi...
These cases were referred to as ADTDP + FL because full-length TDP-43 was presumably present in the aggregates. FTLD-TDP cases showed a similar molecular TDP-43 pattern. A second pattern, which was not seen in FTLD-TDP, was observed in most of p-preAD, as well as 30 neuropathologica...
The full coding sequence of human TDP-43 (Uniplot ID: Q13148) wild type (WT) and its mutant (G348C) were synthesized by Genescript and were inserted into pUC57 vector (Addgene). To construct the plasmid pUAST-TDP-43(WT) and pUAST-TDP-43(G348C), the full coding sequence of human ...