Full size image As an initial step in the drug screening process, we focused on assessing the potential of the screened drugs to rescue the pupal lethality associated with the expression of either wild-type TDP-43 or the TDP-43 G348C mutant specifically in motor neurons. The drugs were admi...
Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 and full-length tau, which allow the quantification of...
These cases were referred to as ADTDP + FL because full-length TDP-43 was presumably present in the aggregates. FTLD-TDP cases showed a similar molecular TDP-43 pattern. A second pattern, which was not seen in FTLD-TDP, was observed in most of p-preAD, as well as 30 neuropathologica...
On the other hand, we observed a reduction in wild-type TUBA4A mRNA as well as full-length TUBA4A protein levels in the R64Gfs*90 TUBA4A patient, pointing towards haploinsufficiency as a possible underlying pathogenic mechanism. However, we cannot fully exclude the possibility that a shortened...
Tpc (Sindan Pharma SRL, Romania) was administered intraperitoneally at a single dose of 0.5 mg/kg; Tdp1 inhibitor 3ba was administrated intraperitoneally at a single dose of 20, 40, or 80 mg/kg (for Krebs-2), or 120 mg/kg (for LLC) in 15% dimethyl sulfoxide (DMSO)–10% Tween-80...