To confirm that the expansion of CAR-T cells and development of xenogeneic GVHD after leukemia eradication was induced by endogenous TCR expressed in CAR-T cells, we ablated TCR expression by targeting the TCR alpha constant region with the CRISPR/Cas9 system. The knockout efficiency was ~30%...
4 weeks ago I was told they’d reviewed my 28 day sample and had found some CLL cells – still below the technical definition of undetectable so it was right to say I had no detectable disease by the usual standard of 0.001 but at UMRD5 I had 0.0002 detected. I was completely thrown...
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