英文名称:Tocilizumab Injection 汉语拼音:Tuozhudankang Zhusheye 【成份】主要活性成份:托珠单抗 托珠单抗是一种重组人源化抗人白介素6(IL-6)受体单克隆抗体,由中国仓鼠卵巢(CHO)细胞通过DNA重组技术制得。 分子式:C6428H9976N1720O2018S42 (仅多肽部分) ...
托珠单抗(Tocilizumab,TCZ)有关文献搜集 罕见病友临行疾呼 多发性硬化MS热心大史:视神经脊髓炎NMOSD关注MOGAD Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneou… 阅读全文 4款(泽布替尼、BCMA CAR-T、本维莫德、百奥泰托珠单抗)国产创新药成功闯关FDA,进入美...
Gabay C, Emery P, van Vollenhoven R, Dikranian A, Alten R, Klearman M, Musselman D, Agarwal S, Green J, Kavanaugh A (2012) Tocilizumab (TCZ) Monotherapy is superior to adalimumab (ADA) Monotherapy in reducing disease activity in patients with rheumatoid arthritis (RA): 24-week data ...
托珠单抗注射液(Tocilizumab,TCZ;商品名:Actemra,雅美罗)是一种人源化单克隆抗体,以可溶性和膜结合性的白细胞介素6受体(sIL-6R和mIL-6R)为靶点,阻断了IL-6与上述受体的结合,从而抑制sIL-6R和mIL-6R介导的信号传导和基因激活。 目前有评估托珠单抗(TCZ)皮下剂型(SC)单用或联合甲氨蝶呤(MTX)治疗与甲氨蝶呤...
Igawa的团队将tocilizumab(Tcz)进行了工程改造,这是一种用于治疗类风湿性关节炎的已批准的人源化抗体,使其在pH依赖性下与IL-6R结合。Tcz既与膜结合型IL-6R结合,也与可溶性IL-6R结合。然而,由于IL-6R的高表达水平,Tcz被迅速清除。该团队将Tcz改造为一种“sweeping” 抗体,共分为两步。首先,他们工程化改造改...
Tocilizumab (TCZ) has been widely used for rheumatoid arthritis (RA) in adults, and the effectiveness for systemic JIA has been well-documented. However, the experience on pJIA is limited. We compared the clinical courses of our patients of RA and pJIA to estimate the effectiveness of TCZ....
Gabay DC, Emery P, van Vollenhoven R, et al. Tocilizumab (TCZ) monotherapy is superior to adalimumab (ADA) monotherapy in reducing disease activity in patients with rheumatoid arthritis (ra): 24-week data from the phase 4 ADACTA trial. Ann Rheum Dis 2012;71(Suppl 3):152....
Use of Tocilizumab (TCZ) to prevent acute graft versus host disease (GVHD),Royal Brisbane and Women's Hospital,Interventional,Phase 2
Objective To investigate whether leucine-rich alpha-2 glycoprotein (LRG) could be a disease activity biomarker of rheumatoid arthritis (RA) during IL-6 blockade.Methods Serum LRG levels in RA patients treated with tocilizumab for 24 we... M Fujimoto,S Serada,K Suzuki,... - 《Arthritis & Rhe...
摘要: This (amended) paper reviews the role of tocilizumab in ameliorating the cytokine storm of interleukin-6 (IL-6) and includes new data on how SARS-CoV-2 causes large artery stroke and why this virus exhibits a high lethal of lethality and communicability.年份: 2020 ...