TCR-induced NF-kB activationa crucial role for Carma1, Bcl 10 and MALT1, ArtículoT-cell receptor (TCR) engagement induces the maturation of thymocytes and the activation and proliferation of peripheral T cells through signaling pathways that target several transcription factors. The transcription ...
BTLA通过Y257和Y282优先招募SHP-1,从而有效促进CD28和CD3ζ的去磷酸化。此外,BTLA还通过与BCR信号体络合并招募SHP-1,减少B细胞增殖和细胞因子分泌,导致Syk激酶的去磷酸化和PLCγ2和NF-kB的活性降低。 TIM-3信号通路 T细胞免疫球蛋白粘蛋白-3(TIM-3)属于TIM蛋白家族,在Th1、CD4+、CD8+T细胞、NK细胞和树突状...
组,NF—KB活化,以及与多个信号通路密切相关的蛋 白分子,如PI-3K和PKC0等,在信号通路中的作用 有了更深刻的了解,本文就这方面的进展作一简要 综述. 1TCR/CD3近膜区的信号复合体 TCR是细胞表面的抗原受体,通常以异源二聚 体形式存在,有o~13和/8两种异源二聚体.95% 以上的胸腺细胞和外周T淋巴细胞都表达TCR...
In a previous study, we documented that the differential effects of ITAM reduction on downstream signalling pathways, most notably attenuation of Akt activation and relative sparing of the calcium and NF-kB pathways favors Treg development and results in an increase in the number of both thymus ...
16、不管受体复合物的组成如何,已充分确定所述复合物将细胞表面结合事件转化为细胞内磷酸化信号传导级联。这些磷酸化事件最终导致转录因子(例如nfat和nfkb)的激活,从而导致细胞因子和效应蛋白(例如颗粒酶和穿孔素)的表达增加。 17、然而,尽管使用这类tce治疗癌症仍然是个有吸引力的概念,但迄今为止,甚至在早期临床开发...
NFKB2 encodes the p100/p52 protein, a critical mediator of the canonical and noncanonical NFkB signaling pathways. Here we report the comprehensive immune ... AW Lindsley,Y Qian,CA Valencia,... - 《Journal of Clinical Immunology》 被引量: 46发表: 2014年 Chimeric immune receptors (CIRs) spe...
PTCL-NOS expresses the highest levels of JUNB, BLIMP1, RelB, BLIMP1 and JUNB are two NF-kB genes that are important in p52 and CD30. T-cell differentiation.44 BLIMP1 (also called PRDI-BF1 in humans) is The first objective of the study was to investigate whether the encoded by the...
Peng B, Gu Y, Xiong Y, Zheng G, He Z (2012) Microarray-assisted pathway analysis identifies MT1X & NFkappaB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma. PLoS ONE 7:e51413 CrossRef Gu Y, Fan S, Liu B, Zheng G, Yu Y et al (2011) ...
DAG激活PKCθ和MAPK/Erk 通路,二者均可促进转录因子NF-κB活性。IP3触发Ca2+从ER释放, 并促使细胞外 Ca2+通过钙离子释放活化Ca2+ (CRAC)通道进入细胞。钙离子结合的钙调蛋白 (Ca2+/CaM) 激活钙调磷酸酶,后者通过转录因子NFAT促进IL-2的基因转录。取决于细胞类型和环境,这些通路中某些位点的反馈调节可得到不同...
Neoantigens derived from non-synonymous somatic mutations are restricted to malignant cells and are thus considered ideal targets for T cell receptor (TCR)-based immunotherapy. Adoptive transfer of T cells bearing neoantigen-specific TCRs exhibits the ab