TCR样抗体将识别肿瘤多肽/MHC复合物的良好特异性与抗体的生物学和药理学特性相结合, 其可能是肿瘤免疫治疗的下一代疗法,并在临床上具有广阔的应用前景。 参考文献1. Qinghua He, et al., TCR-like antibodies in cancer Immunotherapy, Journal of Hematology & Oncology,2019.2. Martin A. Cheever, et al., T...
Creative Biolabs now provides TCR-like antibody discovery service using various world-leading strategies to our worldwide clients for academic or clinical purposes.
More importantly, these TCR-like mAbs mediated both complement-dependent and antibody-dependent cellular cytotoxicity of these cell lines in vitro. This finding suggests the utility of TCR-like mAbs against target cells of closely related HLA subtypes, and the potential applicability of similar ...
参考文献 Rahel Frick et al.A high-affinity human TCR-like antibody detects celiac disease gluten peptide–MHC complexes and inhibits T cell activation. SCIENCE IMMUNOLOGY(2021 Aug 20) doi:https://doi.org/10.1126/sciimmunol.abg4925 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、...
TCR-Like Antibody AbTCR Vector Products DNA-encoded mAb CAR Animal Cells Stable Cell Line Platforms CellRapeutics™ CAR Technology CellRapeutics™ TCR Technology CAR × TCR Bispecific T Cell Engineering Platform Surfarray™ Cell Microarray Technology T-Scan Platform for T Cell-Specific Epitope ...
Additionally, TCR-like antibody ligand binding appears to play an important role in ADC functionality and should be addressed during therapy development to avoid binding patterns that negate ADC killing efficacy. 展开 关键词: Antibody drug conjugate cancer duocarmycin human leukocyte antigen ...
TCR疗法起源于1986年,巴塞尔免疫研究所Michael Steinmetz博士首次将一个T细胞的TCR基因转移到另一个T细胞中,从而赋予第二个T细胞相同的抗原特异性。2002年,Rosenberg团队率先从黑色素瘤组织中分离出肿瘤浸润淋巴细胞(Tumor infiltrating lymphocyte,TIL),体外扩增回输后特异性杀伤黑色素瘤细胞,但由于TIL的提取扩增工艺等难点...
TCR类抗体(TCR mimic antibody,TCR mAb, TCRm)主要是通过筛选出亲和力和特异性远高于TCR的抗体来替代TCR,即将TCRαβ结构域替换为抗体片段的可变域,从而做到有效靶向胞内/外抗原。TCR类抗体拥有抗体的优良成药性以及较长的半衰期,兼具TCR独有的识别细胞内抗原的特性,是近年来逐渐兴起且拥有巨大发展潜力的新型免疫治...
1.a protein molecule, usu. on the surface of a cell, that is capable of binding to a complementary molecule, as a hormone, antibody, or antigen. 2.a sensory nerve ending or sense organ that is sensitive to stimuli. [1900–05]
Functional comparison of engineered T cells carrying a native TCR versus TCR-like antibody–based chimeric antigen receptors indicates affinity/avidity thresholds. J Immunol. 2014;193:5733–43. Article CAS PubMed Google Scholar Isakov N. Immunoreceptor tyrosine-based activation motif (ITAM), a ...