In this study, we demonstrate that the strength of TCR catch bonds significantly influences CD8’s role in determining TCR specificity. Using single-molecule biophysical and functional analyses, we reveal that naturally evolved TCRs form optimal catch bonds with cognate pMHCs. These optimal bonds fac...
In this study, we demonstrate that the strength of TCR catch bonds significantly influences CD8’s role in determining TCR specificity. Using single-molecule biophysical and functional analyses, we reveal that naturally evolved TCRs form optimal catch bonds with cognate pMHCs. These optimal bonds fac...
Full size image Sensitivity and specificity of combinatorial TCR library screens With the aim to exploit the capacity of the genetic screening platform to identify antigen-specific TCRs from highly complex libraries (Fig.3a), we explored the feasibility of identifying tumor-antigen reactive TCRs from...
However, this convention does not mean to suggest that force can only change the energy barrier level but not the energy well level in a real protein complex structure; to the contrary, both are possible70. Full size image Besides binding properties of the TCR–pMHC complex, its structural ...
In diseases such as allergic asthma, there is strong, local * Correspondence: r.boyton@imperial.ac.uk 1Lung Immunology Group, Infectious Diseases and Immunity, Department of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK Full list of author information is ...
Note that score threshold is applied to unweighted (see below) full scores, thus has little sense to use in case--scoring-vdjmatchis not set. For VDJmatch scoring the range of scores is[0, 1]and the recommended value for the threshold lies in the range of0.1-0.5. Filtered records will...
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For the chain information it is in CSV format: V_gene,D_gene,J_gene,C_gene,cdr3_nt,cdr3_aa,read_cnt,consensus_id,CDR3_germline_similarity,consensus_full_length TRUST4 also converts the barcode report file to the trust_barcode_airr.tsv file to follow the AIRR format. SMART-Seq dat...
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Specifically, it was found that a large proportion of the TCR chains were non-functional, for various reasons: in many cases the sequences were truncated or contained frameshifts. In other cases, although full length TCR chains were identified they were unable to fold correctly; finally, TCRs...