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A number of CLL mouse models have recently been reviewed by Simonetti et al.13 The authors compared different models and identified the Eμ-TCL1 transgenic mouse (TCL1-tg) as the most similar to aggressive type human CLL, in terms of immunophenotype, BCR repertoire and disease course. ...
trisomy 12 (16%) is associated with an intermediate form of CLL. Nucleotide sequencing has discovered recurrent mutations in a number of genes such asTP53,NOTCH1,SF3B1,BIRC3andATM, which are indicative of derailed multiple pathways in CLL cells. It is also known that p53 mutations result in ...
I edge back into the living room and stand awkwardly in front of the TV, grateful for the cool, solid bowl in my hands. “I didn’t get the job,” I say. A noodle stops halfway into Casey’s mouth. She drops it back into the Styrofoam. “I thought you were too scared to ...
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