Methods Six patients with PCa with the suspicion of LNM on preoperative PSMA-PET/CT underwent [99mTc]Tc-PSMA-I&S RGS (4 salvage LA, 2 primary LA) with intravenous injection of [99mTc]Tc-PSMA-I&S 24 h prior to surgery. Resected samples were isolated manually aiming at the level of single...
(99mTc)-labeled prostate-specific membrane antigen (PSMA)-based image-guided surgery on the oncologic outcomes for patients with primary or recurrent prostate cancer (PCa).Methods This study retrospectively analyzed 54 consecutive patients with PCa who underwent 99mTc-labeled PSMA-based image-guided ...
背景与目的:前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)在前列腺癌细胞表面特异性高表达,是前列腺癌诊断和治疗的极具有吸引力的靶点。放射性核素标记的PSMA小分子抑制剂能够高效、特异性探测前列腺癌病灶并进行分期。本研究初步探讨99mTc标记PSMA小分子抑制剂(HYNIC-Glu-Urea-A,简称99mTc-PSMA)SPECT/C...
目的探讨定量 99Tc m-联肼尼克酰胺(HYNIC)-前列腺特异膜抗原(PSMA) SPECT/CT显像在前列腺癌诊断中的价值。 方法回顾性分析2018年11月至2021年3月间河南省人民医院临床疑诊前列腺癌的56例患者[年龄(69.8±8.0)岁]资料,所有患者的 99Tc m-HYNIC-PSMA SPECT/CT显像均示前列腺放射性摄取增高。依据病理结果将患者分...
[177Lu]Lu-PSMA-617 uptake, in tumors and kidneys, as well as treatment efficacy did not differ between rA1M and vehicle groups. In mice given rA1M, [99mTc]Tc-MAG3 imaging revealed a significantly higher slope of initial uptake at three months compared to mice co-injected with [177Lu]Lu...
However, despite the availability of relatively large observational data, non-specific bone uptake has not been systematically evaluated with other PSMA ligands, such as [18F]F-JK-PSMA-7 and [99mTc]Tc-PSMA-I&S. The aim of this retrospective analysis was to compare the physiological (non-...
Tc-MIP-1404 CZT SPECT-CT versus 68Ga-PSMA-11 PET-CT: diagnóstico por imagen de las metástasis en el cáncer de próstata99mTc-MIP-1404 CZT SPECT-CT versus 68Ga-PSMA-11 PET-CT: Imaging of prostate cancer metastasis Author links open overlay panelA. Saudi a, P. Takhar b, F. Alj...
En el presente estudio, se evaluaron los pacientes con adenocarcinoma de próstata que habían tenido un PET/TC con [68Ga]Ga-PSMA-11 previo al tratamiento. En nuestro centro, los pacientes con una puntuación de Gleason ≥ 7 o PSA total ≥ 10,0 ng/ml (grupos de riesgo intermedio o...
Therefore, we thought that incorporating glutamates into a mercaptoacetyl-containing chelator for the labeling of PSMA ligands with Tc-99m would be desirable. Following this logic, we designed the PSMA ligand BQ0413, which contains 2-napththyl-L-alanine and L-tyrosine in the linker to improve...
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