The IKK (Inhibitor of NF-kappa B kinases)-related kinases TBK1 (TANK-binding kinase-1) and IKK epsilon are crucial signal transduction proteins, which play important roles in NF-kappa B and IRF3/7 activation. In this study, a TBK1/IKK epsilon homolog (termed CgTBK1/IKK epsilon) was ...
However, the role of the non-canonical I kappa B kinases, TBK1 and IKK epsilon, in the pathogenesis of HTLV-1-associated leukemia has not been evaluated. We here show that TBK1/IKK epsilon are crucial pro-survival molecules by maintaining persistent activity of Stat3. Consistent with this ...