研究背景 创伤性脑损伤(traumatic brain injury,TBI)是世界范围内最常见的致死和致残原因之一,可分为直接作用于颅骨的原发性脑损伤和由初始外伤引起的继发性脑损伤。大约50%的患者发生外伤性颅内出血(硬膜外、蛛网膜下腔、蛛网膜或脑实质)...
Traumatic brain injury (TBI) is a major cause of disability and death in traumatic patients. A series of complex pathophysiological mechanisms after TBI break the balance of coagulation and anticoagulation system, resulting in coagulation dysfunction. TBI-induced coagulopathy includes high blood coagulation...
颅脑外伤又称创伤性颅脑损伤(traumatic brain injury,TBI),因脑组织的特殊生理功能。 颅脑外伤患者的麻醉管理专家共识 林献忠(执笔人),于泳浩,张军,赵辉,艾米娜,顾伟,樊理华,李九会,李利彪,马龙先,王国林(负责人) 颅脑外伤又称创伤性颅脑损伤(traumatic brain injury,TBI),因脑组织的特殊生理功能,其损伤后的致残...
局灶性损伤(Focal Injury):由直接作用力造成的局部组织损伤。 > 参考文献 [1] Dai, J. X., Ma, Y. B., Le, N. Y., Cao, J., and Wang, Y. 2018. Large animal modelsof traumatic brain injury. Int. J. Neurosci. 128:243–54.
Blood-brain barrierNeurodegenerationNerve recoveryOur knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the ...
创伤性脑损伤(traumatic brain injury,TBI)患者易出现严重并发症,与创伤后的死亡相关。TBI的异质性,给预测患者预后带来困难,如一些患者恢复良好,而另一些遗留有严重的神经功能残疾。有研究认为,降钙素原(procalcitonin,PCT)是评估多发伤患者预后的生物标志物,检测血清PCT可能有助于评估TBI的严重程度,预测患者预后。印度...
成人创伤性脑损伤(traumatic brain injury,TBI)脑生理学分析显示基于脑血管反应性的高级监测和个体化脑灌注压(cerebral perfusion pressure,CPP)指标的治疗方案具有潜在应用价值,即最佳CPP(termed optimal CP,CPPopt),表明对中度/重度TBI患者的治疗将朝着更加个性化的方向发展。既往研究显示个体化目标的CPP与对所有患者使...
Traumatic brain injury (TBI) remains a leading cause of death and disability that places a great physical, social, and financial burden on individuals and the health system. In this review, we summarize new research into the metabolic changes described in clinical TBI trials, some of which have...
Traumatic brain injury has become the leading cause of morbidity and mortality all over the world. Early establishment and maintenance of airway is critical as mortality increases in patients who suffer hypoxia. This review discusses the prehospital and intraoperative management of airway in these patien...
Yu J, Zhang Y, Ma H, et al. Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in ratcerebral cortexfollowing traumatic brain injury. Mol Brain 2020; 13(1): 11 END 本文系欧易生物原创 转载请注明本文转自欧易生物