uberculosis antigen-based skin test IFN-γ Interferon gamma 1. Introduction Tuberculosis (TB), an ancient disease, remains a major global killer. In 1882, Robert Koch reported the successful isolation of the causative agent, Mycobacterium tuberculosis [1], an aerobic, non-motile, rod-shaped acid...
Despite eliciting TB-specific immune responses, none of the investigational regimes conferred a protective effect by standard readouts of TB compared to non-vaccinated controls, while lack of protection by BCG underpinned the stringency of this non-human primate test modality. Yet, TB manifestation ...
diagnostic services in low and middle-income countries (LMICs) represent a challenge for current TB diagnostics. Future research should be focused on developing an accurate and rapid biomarker-based test that can diagnose all forms of TB using non-sputum samples, ideally one suitable for use in b...