We conducted a study to determine the prevalence of active \{TB\} and performance of specific screening tests for \{TB\} in adolescents in a high burden setting. Adolescents aged 12–18 years were recruited from high schools in a rural town in South Africa. Participants were screened for ...
Methods Sixteen in-depth interviews were conducted with key informants including healthcare providers and administrators who participated in the trial in Matlosana, South Africa. The participants' experience with symptom-based screening, study implementation strategies, and ongoing challenges with child ...
Therefore, this chapter covers the current WHO-endorsed tests and advances in diagnostic and screening tests for active and latent TB.Previous chapter in volume Next chapter in volume Keywords Tuberculosis Latent TB infection Mycobacterium tuberculosis Nucleic acid amplification test Tuberculin skin test ...
Importantly, this regimen is suitable for use in HIV infected patients, and may offer a useful tool to prevent development of active TB disease [46]. Shorter regimen will help address gaps in patient adherence and regimen completion. It is important to note however, that gaps in screening and...
A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis In the absence of a validated animal model and/or an immune correlate which predict vaccine-mediated protection, large-scale clinical trials...
Mathematical models are able to inform us of the likelihood that, with or without control strategies such as screening and vaccination, the disease can be eliminated or will persist at a specified level of endemicity. Modeling in crowded environments ...
Testing for TB in someone who has symptoms is not the same as the TB screening skin tests that many people get. The skintestjust shows whether someone has been exposed to TB at some time, and may warrant further testing to ensure they don't have a latent case. ...
The description of these RNA signatures is opening the possibility for developing large-scale point of care screening tests as well as targeted (personalized) intervention to prevent the disease and, in patients with active tuberculosis, create customized treatment plans [36]. However, the diagnosis ...
South Africa was one of the countries considered by the 8 models including the necessary HIV structure for this context, and it was found that a combination of continuous IPT for PLHIV on ART, TB screening at health facilities, and improved TB care could reduce TB incidence and mortality in ...
Relatively few studies have looked specifically at the sub-group of individuals on anti-TB treatment who also meet the criteria for alcohol use disorders in South Africa (SA). This study forms part of a larger study entitled: Screening and brief interventions for hazardous and harmful alcohol use...