An internal monitor will review procedures on an annual basis, including assessing adherence to the intervention procedures. Relevant concomitant care permitted or prohibited during the trial {11d} Participants may not be enrolled in another clinical study involving follow-up time points that conflict ...
In addition to increasing screening frequency, we found that improving TB symptom questionnaire sensitivity, second-line TB treatment delays, default before initiating TB treatment or ART, and second-line TB drug efficacy were significantly associated with even greater reductions in TB and HIV cases. ...
India grapples with an alarming burden of tuberculosis (TB), reporting 2.6 million incident cases in 2023, necessitating intensified efforts toward TB elimination. The prevalence of catastrophic costs, defined as expenses exceeding 20% of annual househol
In the context of South Africa, Soweto and Matlosana are 160 km apart and annual TB incidence in the Dr. Kenneth Kaunda District, within which Matlosana is located, is 800/100,000; approximately twice that of the Johannesburg Metropolitan Council within which Soweto is located. Both sites ha...
This means that the time period considered in the analysis is important: the annual INB only becomes positive in the higher-burden setting in year 2 or 3 (depending on the strategy) and in the medium-burden setting in years 2–5; the longer the time-period that is considered the more ...
Among 495 registered migrants who had undergone an annual health check-up, 105 reported having experienced at least one TB-suspicious symptom in the period following the last check-up. Adjusting for the variable duration of the post-check-up period, the estimated one-year period prevalence of TB...
MRC CTU is responsible for annual onward reporting of a line listing of events to the trial sponsor, University College London (UCL). Investigators are responsible for reporting all SAEs, notable events and other adverse events meeting their reporting requirements that occur from the time of ...
Any instrument, screening tool, or questionnaire must be validated. Validating the TBRSS ensured that the tool will detect smokers with a high risk for TB disease quickly and efficiently for the patient [20,21]. The content validation study for the TBRSS focused on the relevancy of the chosen...