However, this route of administration passes through the body's first-pass metabolism which reduces the drugs' bioavailability and toxicates the liver and kidneys. Inhalation therapy represents an alternative to the oral route, but low deposition efficiencies of delivery devices such as nebulizers ...
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KawatkarSP, KeatingTA, OlivierNB, et al. Antibacterial inhibitors of gram-positive thymidylate kinase: structure–activity relationships and chiral preference of a new hydrophobic binding region.J Med Chem. 2014;57(11):4584–4597. doi:10.1021/jm500463c24828090 ...
Next day, 100 μl serum samples at different dilution (made in blocking buffer) starting from 1: 500 to 1: 256000 were added to each well and incubated for 1 h at 37 °C. After that, 100 μl of anti-human IgG- HRP conjugated secondary antibody (1: 20000) was added to ...
(0–t),Cmaxandt1/2were 19,823 ± 1665 μg L−1 × h, 0.63 ± 0.28 µg mL−1and 35.6 ± 2.7 h, respectively, after oral administration of 10 mg kg−1TB47, and the bioavailability was 38.1%. The long half-life and high blood ...
(1) Background: Tuberculosis (TB) is one of the world’s top infectious killers, in fact every year 10 million people fall ill with TB and 1.5 million people die from TB. Vitamins have an important role in vital functions, due to their anti-oxidant, pro-
On day 4 of admission the patient was commenced on TB treatment for disseminateedd (miliiaarryy)) TB and TB meningitis, including oral isoniazid, rifampicin, pyrazinamide and ethambutol, together with intramuussccuullaarrssttrreeppttoommyycciinnaannddiinnttrraavveennoouuss(I(VIV))ddeexxaamme...
Nebulizer 500 µg q20min x 3 then q2-4hrs for adults and 250- 500 µg for children. 7 mg/kg loading dose over 20 min followed by 0.4mg/ kg/hr continuous infusion. Inhaled: tachycardia, skeletal muscle tremor, headache, and irritability. At very high dose hyperglycemia, hypokalemia....
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NSCL-C · The following regimens were added for Concurrent Chemotherapy/RT: "Carboplatin AUC 5 on day 1, pemetrexed 500 mg/m2 on day 1 every 21 days for 4 cycles; concurrent thoracic RT (nonsquamous)" "Cisplatin 75 mg/m2 on day 1, pemetrexed 500 mg/m2 on day 1 every 21 days for ...