The most common dosing protocol is to take 2.0 or 2.5 mg of TB-500 twice per week for four to six weeks, and then reduce to a lower dosing rate such as once or twice per month for maintenance. The body of knowledge is as yet limited with regard to TB-500 dosage. The above protoco...
ACKNOWLEDGEMENTS We are particularly grateful for the family who supported our publication of their case to benefit other families. WEB RESOURCES Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources (DECIPHER), http://decipher.sanger.ac.uk Database of Genomic Variants (...
TBX1 is considered a critical determinant in the pathogenesis of DGS/VCFS because many of the characteristic abnormalities of the syndromes are also displayed in Tbx1 knockout mice (Jerome and Papaioannou, 2001), in mice with altered Tbx1 dosage (Liao et al., 2004), and in humans with TB...
Strict control of RA dosage in the POM is likely crucial for proper cochlear coiling. CD, cochlear duct; ED, endolymphatic duct; POM, periotic mesenchyme. Full size image Tbx1may regulate RA activity Our data support a model in which Brn4 and Tbx1 act cooperatively on the same downstream ...
(IC50 > 30 µM), suggesting a low risk for cardiotoxicity. A single oral administration of 2000 mg kg−1of TB47 or oral 200 mg kg−1daily for 4 weeks, the highest dosage we tested, was well tolerated by mice. No genotoxicity or obvious CYP inhibition was associated ...
Kanamycin has been a widely used injectable for MDR-TB, but amikacin is rapidly replacing it in the increasingly uncommon situations in which injectables are needed. Capreomycin, a related nonaminoglycoside parenteral bactericidal drug, has dosage, effectiveness, and adverse effects similar to those ...