Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice. Neurobiol. Learn. Mem. 104, 73-81. doi: 10.1016/j.nlm.2013.05.005Reichelt AC, Killcross S, Wilkinson LS, et al. (2013) Transgenic expres- sion of the FTDP-17 tau ...
Neurofibrillary tangles (NFTs) are neuronal inclusions of microtuble-binding protein tau and are composed of phosphorylated and ubiquitinated tau aggregations that form 尾pleated sheet structures. Given this, NFT-bearing neurons are ubiquitin- and phosphorylation dependent tau-immunoreactive, argyrophilic, ...
Tanemura K, Akagi T, Murayama M, Kikuchi N, Murayama O, Hashikawa T, Yoshiike Y, Park JM, Matsuda K, Nakao S, Sun X, Sato S, Yamaguchi H, Takashima A. Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol Dis. 2001; 8 :1036–1045....
Accumulation of toxic tau species in V337M MAPT neurons was correlated with increased vulnerability to pro-apoptotic stress. Notably, this mutation-associated cell death was pharmacologically rescued by the inhibition of effector caspases. Conclusions Our results suggest an upstream, time-dependent ...
P1-098: Brain changes underlying increased impulsivity in transgenic mice expressing the human FTDP-17 tauV337M mutationdoi:10.1016/j.jalz.2006.05.473Sarah L. LambourneTrevor HumbyRichard T. IbitoyeWilliam DaviesAnthony R. IslesPiers C. Emson...
Acetyl-Ile-Gly-Leu protects neurons from Aβ1–42 induced toxicity in vitro and in V337M human tau-expressing miceXiong, Z. M.Kitagawa, K.Nishiuchi, Y.Kimura, T.Nakamura, T.Inagaki, C.LIFE SCIENCES
P3‐200: TAU‐MEDIATED CELL DEATH MECHANISMS IN MAPT V337M IPSC‐DERIVED HUMAN NEURONSdoi:10.1016/j.jalz.2019.06.3229Theofilas, PanosHayath, MifrahWang, ChaoButler, DavidMcAllen, SalomeArkin, MichelleGestwicki, JasonCuervo, Ana MariaKayed, Rakez...