作者: A Ghirelli,N Tosakulwong,SD Weigand,HM Clark,F Ali,H Botha,JR Duffy,RL Utianski,M Buciuc,ME Murray 展开 摘要: Objective To examine associations between tau and amyloid‐beta (Aβ) molecular PET and both Alzheimer‐related pathology and 4‐repeat tau pathology in autopsyヽonfirmed ...
HASV402552P0002 TSG-912-N11-L11 TSG912X22L22 TSG-912-X22-L22 Trip Circuit Supervision TSG-912-X22-L22`中液`淮安通淮工贸有限公司`齿轮泵 CBN-F3 CBN-F316 台湾`HSING HAO兴豪`中心校正机红外线对中控制器RG1199 对中光电管 总长2520,总长2640MM `BONFIGLIOLI GROUP`BONFIGLIOLI RIDUTTORI S.P.A ...
The noradrenergic nucleus locus coeruleus (LC) is a key hub of the mammalian brain, connecting to virtually all parts of the central nervous system [12,40,45,91,98]. In humans, LC harbours around 22-52.000 pigmented neurons [16,43], forming an elongated, rod-like bilateral structure in ...
In light of the failure of the clinical trials with amyloid targeting drugs, tau therapy is manifesting as the frontrunner in the search for an effective treatment for AD. Tour de tau - tau as a protein with multiple faces In contrast to amyloid precursor protein (APP), the function of ...
are required for process outgrowth to damaged tissue [125,193] and also modulate synaptic plasticity in visual cortex [280]. A more direct pathway is a surprising new role for the complement system. Complement initiation factor C1q tags synapses for removal in an activity dependent manner. This ...
initiation site. Initiation of prion-like seeding in transgenic mice expressing mutant TauP301S, in entorhinal cortex resulted in spreading of Tau-pathology along functionally connected circuits, resulting in impaired LTP in hippocampal CA1 neurons. Cognition measured in an object recognition task was ...
ARTICLE DOI: 10.1038/s41467-017-00618-0 OPEN Tau exacerbates excitotoxic brain damage in an animal model of stroke Mian Bi1, Amadeus Gladbach1, Janet van Eersel1, Arne Ittner1, Magdalena Przybyla1, Annika van Hummel1, Sook Wern Chua1, Julia van der Hoven1, Wei S. Lee1, Julius ...