18.Pontecorvo, M. J. et al. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. Brain 140, 748–763 (2017). 19.Sepulcre, J. et al. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat. Med. 24,...
Senile plaque is an extracellular structure composed of b-amyloid protein (Ab), with peptides of approximately 40 amino acids cleaved from the Ab precursor protein. Neurofibrillary tangles are a bundle of abnormal, paired helical filaments, of which hyperphosphorylated tau protein is the principal ...
Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years, the prevailing view of AD pathogenesis has been that changes in Aβ pr
Amyloid β accelerates age-related proteome-wide protein insolubility
Villemagne, V. L., Dore, V., Burnham, S. C., Masters, C. L.& Rowe, C. C. Imaging tau and amyloid-beta proteinopathies in Alzheimer disease and other conditions. Nat. Rev. Neurol.14, 225–236 (2018).Ossenkoppele, R. et al. Tau PET correlates with different Alzheimer’s ...
18.Pontecorvo, M. J. et al. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. Brain 140, 748–763 (2017). 19.Sepulcre, J. et al. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat. Med. 24,...
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Amyloid-β are proteolytic fragments of the amyloid precursor protein, whereas is a brain-specific, -enriched -associated protein. The behavioral symptoms of AD correlate with the accumulation of plaques and tangles, and they are a direct consequence of the damage and destruction of that mediate ...
Regional distribution of tau, beta-amyloid and beta-amyloid precursor protein in the Alzheimer's brain: a quantitative immunolabelling study. 来自 Semantic Scholar 喜欢 0 阅读量: 33 作者:C Shukla,LR Bridges 摘要: Regional variation in the distribution of SP and NFT within the brain is well ...
K. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer’s disease brain is associated with mitochondrial dysfunction. J. Neurosci. 26, 9057–9068 (2006). Article CAS PubMed PubMed Central Google Scholar Mairet-Coello, G. et al. The CAMKK2-AMPK ...