2、Ou, Y. N. et al. Blood Pressure and Risks of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of 209 Prospective Studies. Hypertension 76, 217-225, doi:10.1161/HYPERTENSIONAHA.120.14993 (2020). 3、Hu, H. et al. Tau pathologies mediate the association of blood ...
同样,认知弹性与颞下回(IT)FTP 或者整个颞叶(MetaROI)PiB DVR之间存在并不显著的负相关趋势(r = −0.104,P = 0.25;r = −0.168,P = 0.06)。 作者假设,更高的综合弹性得分应该与较少的认知能力下降有关。为了验证这些关系,作者使用线性混合效应模型进行纵向数据分析。在ERC FTP预测情景记忆的模型中,认知...
但是，小胶质细胞也可能中和Aβ和其他一些有毒的类tau蛋白的物质，从而延迟了病理扩散和其所导致的神经退行性变。而更进一步，因为TREM2的缺失，与斑块相关的小胶质细胞的继发性损失，也能增强tau病化的扩散。这表明TREM2可能可以指示包含tau的小胶质细胞来减轻tau病理症状。 结语 在现今的阿尔茨海默病的治疗发展中...
研究方法 本研究遵循系统评价和荟萃分析的首选报告项目(Preferred Reporting Items for Systematic Reviews and Meta-Analysis,PRISMA)指南,在 MEDLINE(通过 PubMed)、Scopus(通过 EBSCO)和 Web of Science 数据库中检索截至 2024 年 7 月 31 日的相关研究。纳入标准为:报告 AD 连续体(即轻度认知障碍(mild cognitive...
【2】Scheltens P, et al (2016) Alzheimer’s disease.Lancet (Lond Engl)388:505–517. 【3】Olsson B, et al (2016) CSF and blood biomarkers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis.Lancet Neurol15:673–684. ...
Data of tau protein were collected and analyzed by Meta-analysis by using Stata11.0. Publication bias was estimated by Egger's regression test and sensitivity analysis was made. Results Eleven studies met inclusion criteria, 9 of them provided complete CSF total tau protein and phosphorylated ta...
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一项涉及9项研究的Meta分析显示, PET诊断AD的敏感性和特异性均为86%【521(I级 证据).②用于AD与其他类型痴呆的鉴别诊断, "F—FDG PET脑代谢异常与NINCDS—ADRDA临床 诊断"很可能AD"的符合率高.18F-FDG PET脑扫描 显示不同类型痴呆脑内代谢异常的区域不同,这是 各种类型痴呆间鉴别的重要依据[5蛳】.Salmon ...
R. H. Myers, M. A. Pericak-Vance, N. Risch, C. M. van Duijn, Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer ...
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We co