( 2007 ) Functional silencing of TATA-binding protein (TBP) by a covalent linkage of the N-terminal domain of TBP-associated factor 1 . J. Biol. Chem. 282 , 22228 – 22238 .Mal TK, Takahata S, Ki S, Zheng L, Kokubo T, Ikura M (2007) Functional silencing of TATA-binding protein ...
Loss of normal huntingtin function: new developments in Huntington's disease research ElenaCattaneo, ...SimonettaSipione, inTrends in Neurosciences, 2001 Various authors have shown that transcription factors such as CBP [CREB (cAMP-response element binding protein)-binding protein]14,TATA-binding prote...
Saccharomyces cerevisiae contains a protein which is functionally similar to the mammalian TATA element-binding transcription factor, TFIID. The yeast factor substitutes for TFIID in a mammalian RNA polymerase II in vitro transcription system, forms a stable preinitiation complex on the Adenovirus-2 major...
The TATA binding protein (TBP) is required at RNA polymerase I, II, and III promoters that either contain or lack a TATA box. In an effort to understand how TBP might function at such a wide variety of promoters, we have investigated the specific and nonspecific DNA binding properties of ...
The TATA-binding proteins function as a part of the TFIID, the huge transcription factor which initiates the transcription process. Once it associates with the promoter, it assigns the extra transcription factors and a string of them to associate. This leads to the construction of a huge protein...
Assessing a potential correlation between protein stability and function of the HMG domain of Lymphoid Enhancer Binding Factor-1 热度: TheBindingInteractionofHMG-1withtheTATA-bindingProtein/ TATAComplex* Receivedforpublication,December29,2000,andinrevisedform,May29,2001 ...
Wet lab experimental procedures are not only time-consuming, but also costly, so predicting protein structure and function reliably based only on amino acid sequence has significant value. TATA-binding protein (TBP) is a kind of DNA binding protein, which plays a key role in the transcription ...
TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to ...
Function : General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polym...
One of these gens, SPT15, encodes the TATA-binding protein, and three others, SPT3, SPT7, and SPT8, encode proteins functionally related to the TATA-binding protein. To identify additional related functions, we have selected for new spt mutations. This work has identified one new gene, ...