Inhibition of TATA-binding protein function by - Belotserkovskaya, Sterner, et al. - 2000 () Citation Context ...equired for GAL1 activation (30). While Spt3 stimulates TBP binding to the GAL1 promoter, other experiments suggest that Spt3 can act oppositely, inhibiting TBP binding to the...
Loss of normal huntingtin function: new developments in Huntington's disease research ElenaCattaneo, ...SimonettaSipione, inTrends in Neurosciences, 2001 Various authors have shown that transcription factors such as CBP [CREB (cAMP-response element binding protein)-binding protein]14,TATA-binding prote...
DNA damage may compromise protein binding, thereby affecting function. We have studied the effect of TATA-binding protein (TBP) on damage formation by ultraviolet light and on DNA repair by photolyase and nucleotide excision repair in yeast and in vitro. In vivo, selective and enhanced formation ...
Clearly both structure and dynamics contribute to TBP·TATA function. The AdMLP sequence alone shows only a slight increase in the value of ς, the S.D. of the end-to-end distance distribution, upon TBP binding. A plausible hypothesis is that the complementarity of the protein-duplex ...
Function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymer...
Wet lab experimental procedures are not only time-consuming, but also costly, so predicting protein structure and function reliably based only on amino acid sequence has significant value. TATA-binding protein (TBP) is a kind of DNA binding protein, which plays a key role in the transcription ...
bindingprotein(TBP)andagroupofevolutionarilyconservedproteinsknownasTBP-associatedfactorsorTAFs.TAFsmayparticipateinbasaltranscription,serveascoactivators,functioninpromoterrecognitionormodifygeneraltranscriptionfactors(GTFs)tofacilitatecomplexassemblyandtranscriptioninitiation.ThisgeneencodesTBP,theTATA-bindingprotein.A...
Function : General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polym...
Abstract DNA-damage formation and repair are coupled to the structure and accessibility of DNA in chromatin. DNA damage may compromise protein binding, thereby affecting function. We have studied the effect of TATA-binding protein (TBP) on damage formation by ultraviolet light and on DNA repair by...
TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to ...