Human Immunodeficiency Virus 1 (HIV-1) exhibits a wide range of interactions with the host cell but whether viral proteins interact with cellular RNA is not clear. A candidate interacting factor is the trans-activator of transcription (Tat) protein. Tat is required for expression of virus genes...
Nukuzuma S, Kameoka M, Sugiura S, Nakamichi K, Nukuzuma C, Miyoshi I, Takegami T (2009) Archetype JC virus efficiently propagates in kidney-derived cells stably expressing HIV-1 Tat. Microbiol Immunol 53(11):621-628Nukuzuma S, et al. 2009. Archetype JC virus efficiently propagates in ...
Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region J. Virol., 81 (2007), pp. 4226-4234, 10.1128/JVI.01888-06 View in ScopusGoogle Scholar 15 H. Sivakumaran, A. van ...
Neuropsychopharmacology (2014) 39, 380–388; doi:10.1038/npp.2013.201; published online 11 September 2013 Keywords: cocaine; drug abuse; HIV-1; neuroAIDS; Tat; transgenic INTRODUCTION Psychostimulants are highly abused in both general and human immunodeficiency virus (HIV)-infected populations (...
The modified virus Ad5.PTDtat was rescued and purified as previously described [53]. In brief, the pAd5.PTDtat plasmid was digested with PacI (to release the viral genome), purified, and transfected into 293 cells stably expressing the complementary E1 genes. After the virus plaques formed,...
Within the genes of HIV virus, the transactivator of transcription (Tat) gene plays a crucial role in regulation of proteins that control how the HIV virus infects cells2,6–8. It has been known that HIV-1 Tat, detected in the brain and the sera of HIV-1 patients9–11, plays an ...
Thirty years of HIV-1 research have led to great advances in the control and treatment of the infection, but there still is a long way ahead in the quest of controlling the virus. The new generation of cART allows HIV-1 infected patients to live longer, almost normal life expectancy lives...
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In the era of combined antiretroviral therapy (cART), human immunodeficiency virus type 1 (HIV-1) is now considered a chronic disease that specifically targets the brain and causes HIV-1-associated neurocognitive disorders (HAND). Endocannabinoids exhibit neuroprotective and anti-inflammatory properties ...