and differentiation of ingested nutritional/poisonous compounds in the oral cavity and gastrointestinal tract.gene variants are associated with alterations in individual sensitivity to bitter taste and food intake; hence, these genetic variants may modify the risk for diet-related diseases, including ...
Hence, this study will analyze the relationship between the classic G145C variation of the TAS2r38 gene (coding for the synonymous A49P polymorphic variants, respectively) with sensitivity to bitter taste and with the pattern of food consumption in this age stratum. Because factors such as age...
The TAS2R38 gene variants were being associated with a variety of bitter tasting dietary foods, alcohol, and nicotine. Hence, we examined the influence of the TAS2R38 gene polymorphisms on the alcohol dependence and tobacco chewing habits among the Koraga tribal population....
However, recent reports have suggested that the carbonic anhydrase 6 (CA6) gene may also influence bitterness sensing. Genetic variants in these genes could influence dietary intake of brassica vegetables, whose increased consumption has been observed in the literature, t...
The aim of this study was to examine TAS2R38 gene polymorphisms among CRSwNP patients and control group (N = 544) with the evaluation of the association between the distribution of studied polymorphic variants and the incidence as well as severity of CRSwNP in the...
The effect of two bitter agonists (6-n-propylthiouracil and quinine) was tested.TAS2R38 mRNA was more expressed inSAT and VAT of obese thanlean subjectsand the expression/protein contentwas greater in mature adipocytes.The expression levels were not linked to P49A variants. In differentiated ...
The expression levels were not linked to P49A variants. In in vitro differentiated adipocytes, bitter agonists induced a significant delipidation. Incubation with 6-n-propylthiouracil induced an inhibition of lipid accumulation rate together with an increase in TAS2R38 and a decrease in genes ...
PTC sensitivity is mediated by the TAS2R38 receptor and its genetic common variants. We study the role of the TAS2R38 receptor in taste disorders with the aim of understanding if these can be genetically determined.Study Design: Prospective cohort study.Methods: Differences in...
This mismatch is fundamental for PCR experiments to amplify specifically one of the two polymorphic variants characterizing the polymorphism. Briefly, for each sample, we arranged two PCR reactions in parallel, combining a common primer and one of the two mismatched primers to detect which kind of...