Preferably, the RRP is of a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is upregulated on HSC during disease. In particular, the RRP may be of a receptor selected from the group of PDGF receptor, collagen type VI receptor, cytokine receptor(s) such as TGF尾, ...
We elucidated the anti-fibrotic effects of neratinib in hepatic stellate cells (HSCs) and in vivo models of CCl4-induced liver fibrosis. HSC activation is a key step in liver fibrogenesis and has a crucial role in collagen deposition, as it is primarily responsible for excessive ECM production....
The functional role of Nestin in hepatic stellate cells (HSCs) was investigated by examining the pathway activity of pro-fibrogenic TGFβ-Smad2/3 signalling and degradation of TGFβ receptor I (TβRI) after interfering with Nestin. The in vivo effects of knocking down Nestin were examined with...
Role of hepatocyte senescence in the activation of hepatic stellate cells and liver fibrosis progression. Cells. 2022;11:2221. Article CAS PubMed PubMed Central Google Scholar Khalil R, Diab-Assaf M, Lemaitre JM. Emerging therapeutic approaches to target the dark side of senescent cells: new ...
Preferably, the RRP is a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is up-regulated on HSC during disease. The RFP may be chosen from among a PDGF receptor, a collagen type VI receptor, cytokine receptor(s) such as TGB尾, INF伪 and interleukin尾. The cyclic ...
(3):289–308. article cas google scholar bansal r, prakash j, de ruiter m, poelstra k. interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo. j control release. 2014a;179:18–24. article cas google scholar bansal r, prakash ...
For example, senescence-related hepatic stellate cells elevate cell surface MICA and ULBP2, ligands of activating receptor NKG2D, on NK cells (Krizhanovsky et al., 2008). Senescent cells may express specific surface antigens, such as major histocompatibility complex class II (MHCII) molecules ...
Robert Barrett.Specific shRNA targeting of FAK influenced collagen metabolism in rat hepatic stellate cells.世界胃肠病学杂志:英文版(电子版).2010.4100-4106Dun ZN,Zhang XL,An JY,et al.Specific shRNA targeting of FAK influenced collagen metabolism in rat hepatic stellate cells .World J Gastro...
HCV-infected hepatocytes and liver macrophages secrete proinflammatory cytokines and chemokines that promote the activation and differentiation of hepatic stellate cells (HSCs) to myofibroblasts that produce extracellular matrix (ECM) components. Prolonged ECM production by myofibroblasts due to chronic ...
et al. hdac5 modulates pd-l1 expression and cancer immunity via p65 deacetylation in pancreatic cancer. theranostics. 2022;12(5):2080–94. article cas pubmed pubmed central google scholar ji t, et al. hdac inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by ...