Targeted Therapy for Metastatic Breast Cancer - HB - 2006 () Citation Context ... exist. * E-mail: xiewj75@126.com (WX); elite010@163.com (WW) . These authors contributed equally to this work. Introduction Metastasis seriously affects the survival of individuals with breast cancer=-=[1...
Targeted Therapy 101 Ibrance Slows Progression of Double-Positive Metastatic Breast Cancer Addition of the CDK 4/6 inhibitor improved progression-free survival by 15.2 months for patients with HR+/HER2+ advanced breast cancer. FDA Approves Ensacove for ALK-Positive Advanced Non-Small Cell Lung Cancer...
Key words: Breast cancer Targeted therapy Oncocardiology参考文献(共36条): [1] Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021,71(3):209-249. [2] An...
3-kinase/mammalian target of rapamycin (PI3K/mTOR), cell-cycle regulation, heat shock protein, and epigenetic pathways] have demonstrated promising activity in clinical trials, and the mTOR-inhibitor everolimus has been approved for advanced or metastatic aromatase inhibitor-resistant ER+ breast cancer...
Several clinical trials have demonstrated the effectiveness of Trop2-targeted therapy in breast cancer. Sacituzumab govitecan (SG) is a Trop2-targeted antibody-drug conjugate (ADC) that has been approved for the treatment of metastatic TNBC and hormone receptor-positive (HR+) and human epidermal...
Clinical application of truly targeted therapy relies on identification of a specific molecular feature (the target) that is biologically relevant, reprodu
Clinical application of truly targeted therapy relies on identification of a specific molecular feature (the target) that is biologically relevant, reprodu
HER2 is an established therapeutic target in a large subset of women with breast cancer; a variety of agents including trastuzumab, pertuzumab, lapatinib, neratinib and trastuzumab emtansine (T-DM1) have been approved for the treatment of HER2-positive breast cancer. HER2 is also overexpressed in ...
Local regional treatment of operable breast cancer over recent decades has evolved to embrace a “less is more” philosophy, from the adoption of breast conserving therapy, to the validation of sentinel node biopsy and more recently investigations into omission of surgery or radiation for biologically...
Background: To review the efficacy of chemotherapy and human epidermal growth factor receptor 2 (HER2)-targeted therapy when used in addition to hormonal t... Buzdar,U A. - 《Annals of Oncology》 被引量: 120发表: 2009年 T-DM1: A novel antibody therapy for metastatic breast cancer treatmen...