2. Introduction Genetic perturbationstudies have been instrumental for delineating causal relationships between genes and phenotypes.同时single-cell transcriptomics provides a greater wealth of data on molecular and cellular phenotypes.因此, pooled CRISPR screens that couple genetic perturbations with single-ce...
This universal perturbation attacks one targeted source class to sink class, while having a limited adversarial effect on other non-targeted source classes, for avoiding raising suspicions. Targeting the source and sink class simultaneously, we term it double targeted attack (DTA). This provides an ...
Run target attack to map these 450 samples to selected target (perturbation budget l_inf=16). Repeat this process for all the 10 targets. Report average target accuracy. Updating...Meanwhile, please have a look at our paper. Unknown Target Model (top) Attacker has access to a pretrained...
关键词: Face recognition Rootkit Perturbation methods Training Error analysis Task analysis Target recognition DOI: 10.48550/arXiv.1812.03128 年份: 2018 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 IEEEXplore IEEEXplore (全网免费下载) arXiv.org (全网免费下载) arXiv.org ResearchGate 查看...
For these cases, we propose an alternative approach: sequential target perturbation (STP) in cancer cells and CAFs might lead to therapeutic efficacy, with targeting of CAFs to block the protumor effect first and then treating cancer cells to realize anticancer effects (Fig. 7d). Third, to ...
Using a novel nontargeted metabolomics approach, we explored the global metabolic perturbation profile for CHD. Blo... Y Li,D Zhang,Y He,... - 《Sci Rep》 被引量: 11发表: 2017年 加载更多 来源期刊 LWT 15 September 2023 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据...
Clonal cultures did not identify any perturbation of granulocyte-macrophage (GM), erythroid, or megakaryocyte progenitors. The number of day-12 colony-forming unit-spleen progenitors were similar in wild-type and IL11Ra-/- mice. The kinetics of recovery of peripheral blood white blood cells, ...
could target genomic regions that cannot be targeted by Cas9 and induce multiplex gene perturbation in vitro with frequencies of up to 45%.309In addition, timed delivery of Cas9-guide RNP (RNA ribonucleoprotein) complexes was used to site-specifically induce DSBs and new genetic information, with...
This cell cycle perturbation by CDK4 disruption was associated with increased binding of p27 to cyclin E/CDK2 and diminished activation of CDK2 accompanied by impaired Rb phosphorylation. Importantly, fibroblasts from CDK4(-/-) p27(-/-) embryos displayed partially restored kinetics of the G(0...
The perturbation data required for our proposed method originates from a drug screen consisting of 60 small molecule inhibitors with quantified kinase interaction behaviors. This drug screen, denoted Drug Screen Version 1.0, consists of two sets of data: (i) The first set is the experimentally gen...