* Since 1946, we have given 5% of our profits to communities in products, cash and through Target Foundation, which today equals millions of dollars a week.Calculated based on the average of the prior three years of Target’s pre-tax profits. Giving includes Target’s product and cash donat...
did not bind knockout OHS cells. Taken together, these data demonstrate that TP antibodies are specific for unique epitopes residing on the antigen, ALPL-1, confirming previous propositions18that the TP target was an alkaline phosphatase of a molecular weight of around 80 kD (Fig.1c). Diff...
The targeting capability of fabricated nanocarriers was then examined. Here, 1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindodicarbocyanine (DiD) was used as a marker instead of RBA (DiD-NPs), to label the uptake of nano-micelles in cells and the fluorescence localization in animals.42First, cel...
Some papers were excluded because the target group was not vulnerable due to a personal characteristic, but rather due to a situational characteristic, or the target group was not a specified group. In other cases, the empowered behaviour was not aimed at a vulnerability of the target group, ...
Additionally, we obtained preliminary data suggesting this inhibitory action was dose-dependent (data not shown). Fig. 5 Effects of YXT and its components on COX-1 and COX-2 activities. COX-1 and COX-2 activity assay kits were used to monitor the COX enzymatic activities. Ethanol extracts ...
Tf-DSF/CuS PTT Glioma C6 cells Tf-DSF/CuS effectively suppressed tumor growth.DSF load did not compromise photothermal conversion ability of CuS nanoparticles. Efficacy of the photothermal ablation therapy of Tf-DSF/CuS was evaluated under 808 nm laser irradiation both in vitro and in vivo. (...
Using the "cds" field in the annotation of the Refseq sequences, the region of the 3' UTR of the genes was defined and determined, whether the homologous region was located in the 3'UTR. As control genes, we used 207 mRNAs whose expression was not changed in the experiment and looked ...
tumor ultimately recurs because the rare therapy-resistant CICs have not been eliminated. These recurrences are often not responsive to subsequent treatment. Conversely, therapies that target CICs, but spare differentiated cells, do not appear to greatly debulk the tumor early on. However, as the CI...
For a long time, sorcin overexpression in MD-resistant cancer cells was considered as an accidental consequence of such genomic co-amplification [50]; on the contrary, in the last two decades, many studies have demonstrated that sorcin is an oncoprotein, and have revealed its role both as a ...
No increase in ppGpp synthesis was observed at 15, 30 or 60 min following addition of vancomycin, but ATP and GTP pools were reduced on average by 23% and 35% after 15 min, respectively (data not shown). MIC tests indicated that a relA mutant strain that is incapable of ppGpp ...