We find that Google indicators can explain a larger percentage of the price increase in target firms before their mergers than the Financial Times. However even the Google proxy of the market expectation hypothesis can only explain at best 36% of the target price run ups. (C) 2012 Elsevier ...
An attractive approach to help accelerate drug development utilizing these genotype–phenotype resources is through applying phenome-wide association studies (PheWAS). PheWAS are an unbiased approach to test for associations between a specific genetic variant, or, more recently, combination of variants, a...
Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG (2011) Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci USA 108(26):10484–10489. doi...
Suitable proteins encoded by primary target genes are the transcription factors BCL6 (B-cell CLL/lymphoma 6), NFE2 (nuclear factor, erythroid 2), POU4F2 (POU class 4 homeobox 2) and ELF4 (E74-like factor 4) in THP-1 cells [83], as well as IRF5 (interferon regulatory factor 5), ...
(Figure 11b). In principle, p53 can do it directly or indirectly, through stimulation of IRF1. The detailed analysis of IRF1 target genes in lung cancer cells will be the subject of another, more extended study. Because the involvement of p53 in regulation of IFIT1 and IFIT3 was not ...
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Metzger-Filho, O.; Sun, Z.; Viale, G.; Price, K.N.; Crivellari, D.; Snyder, R.D.; Gelber, R.D.; Castiglione-Gertsch, M.; Coates, A.S.; Goldhirsch, A.; et al. Patterns of recurrence and outcome according to breast cancer subtypes in lymph node-negative disease: Results from...
Metzger-Filho, O.; Sun, Z.; Viale, G.; Price, K.N.; Crivellari, D.; Snyder, R.D.; Gelber, R.D.; Castiglione-Gertsch, M.; Coates, A.S.; Goldhirsch, A.; et al. Patterns of recurrence and outcome according to breast cancer subtypes in lymph node-negative disease: Results from...