The review also considers gaps in the current knowledge of MYB-DNA interactions, particularly for plant MYB proteins, and how emerging techniques that examine protein-DNA interactions can fill these gaps.Michael B ProuseMalcolm M. CampbellBiochimica et Biophysica Acta. Gene Regulatory Mechanisms...
Analysis of bHLH and MYB domain proteins: species-specific regulatory differences are caused by divergent evolution of target anthocyanin genes. Summary: The regulatory anthocyanin loci,: an1, an2, an4 and an11 of Petunia hybrida, and r and c1 from Zea mays, control transcription of different...
and therefore endocrine-resistant disease may constitute up to one- quarter of all breast cancers.3 The Cancer Genome Atlas (TCGA) consortium reported that most dominant feature of Luminal/ER- positive breast cancers is increased mRNA and protein levels of ESR1, GATA3, FOXA1, XBP1 and MYB. Mo...
Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential tar... The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1), plays an essential role in cell cycle progression by re...
5B-H). Some of these transcription factors have been characterized functionally (Table 1). For example, overexpression of ZmWRKY114 impaired salinity tolerance [43]. ZmMYB42 negatively regulated lignin synthesis, which was activated by ZmMYB69 to inhibit lignin biosynthesis in maize stem [44, ...
In mammalian cells, WTAP was shown to bind the Wilm’s tumor 1 protein, which is critical for embryonic development.45., 46. Interestingly, WTAP levels are closely related to those of METTL3, which was shown to regulate WTAP homeostasis.47 Regarding the other MACOM complex subunits, VIRMA ...
The tom-1 gene has two promoters, one of which is Myb-inducible. tom-1 is expressed at elevated levels in AMV-transformed as well as in E26-transformed myeloid cells. We show that tom-1 activation by v-Myb does not require de novo protein synthesis and that the Myb-inducible tom-1 ...
During a profiling screening for p63 targets by RNA interference (RNAi)-mediated functional inhibition, we identi- fied the High Mobility Group (HMG) box protein 1 (HBP1) as a potential target. First identified in rat brain, on the basis of its ability to suppress the potassium transport-...
XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about the effectors of XBP1 in this con
Leukaemic transformation may be promoted in cases where high MYB levels are maintained1,13, which is the case in many human lymphoid and myeloid acute leukaemias14, where MYB may act as a critical mediator of oncogene addiction15. The MYB protein harbours three functional domains: an N-...