The review also considers gaps in the current knowledge of MYB-DNA interactions, particularly for plant MYB proteins, and how emerging techniques that examine protein-DNA interactions can fill these gaps.Michael B ProuseMalcolm M. CampbellBiochimica et Biophysica Acta. Gene Regulatory Mechanisms...
and therefore endocrine-resistant disease may constitute up to one- quarter of all breast cancers.3 The Cancer Genome Atlas (TCGA) consortium reported that most dominant feature of Luminal/ER- positive breast cancers is increased mRNA and protein levels of ESR1, GATA3, FOXA1, XBP1 and MYB. Mo...
Analysis of bHLH and MYB domain proteins: species-specific regulatory differences are caused by divergent evolution of target anthocyanin genes. Summary: The regulatory anthocyanin loci,: an1, an2, an4 and an11 of Petunia hybrida, and r and c1 from Zea mays, control transcription of different...
The regulatory C1 locus of Zea mays encodes a protein with homology to MYB-related proto-oncogene products and with structural similarities to transcriptional activators. The EMBO J 6:3553-3558 The structure of the wild-type c1 locus of Zea mays was determined by sequence analysis of one genomic...
Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAGV-1, an exclu
Nymphaea (waterlily) is known for its rich colors and role as an important aquatic ornamental plant globally. Nymphaea atrans and some hybrids, including N. ‘Feitian 2,’ are more appealing due to the gradual color change of their petals at different fl
In mammalian cells, WTAP was shown to bind the Wilm’s tumor 1 protein, which is critical for embryonic development.45., 46. Interestingly, WTAP levels are closely related to those of METTL3, which was shown to regulate WTAP homeostasis.47 Regarding the other MACOM complex subunits, VIRMA ...
However, the two proteins have distinct biological activities, and expressing them individually in human cells leads to the activation of distinct sets of endogenous genes, suggesting that each protein has a unique transcriptional specificity. Here, the structural and functional features of the Myb ...
Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential tar... The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1), plays an essential role in cell cycle progression by re...
During a profiling screening for p63 targets by RNA interference (RNAi)-mediated functional inhibition, we identi- fied the High Mobility Group (HMG) box protein 1 (HBP1) as a potential target. First identified in rat brain, on the basis of its ability to suppress the potassium transport-...