d Visualization of PTBP2 eCLIP-seq data from human cortex highlighting two highly enriched PTBP binding regions near SYN- GAP1 exon 11: site 1 (green, intronic site) and site 2 (blue, NMD-inducing Exon 11x). Zoom-ins for both sites are provided including information about the nucleotide ...
Precise location of the p53 binding site has been reported for 266 of the 399 gene-study pairs. In general, the number of p53 binding events decreases with increasing distance from the transcriptional start site (TSS). Proximal p53 binding—that is, within 1 kb from the TSS—occurs most ...
similar to so-called excitation-contraction coupling in skeletal muscle cells. Both ryanodine receptors and L-type Ca channels seem to be colocalized near the axolemma of myelinated axons. However, the blockage of intra-axonal calcium release, e.g. through the L-type calcium channel blocker ni...
Notably, we found no overlap between the genes near set1(RNAi) affected H3K4me3 peaks and those affected by mll1/2(RNAi) in WW H3K4me3-ChIP (Figure 2F), suggesting that Set1 and MLL1/2 operate at distinct loci in planarians. Although we acknowledge the small sample size of the set1(...
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For hAChE, the electron density map corresponding to compound 3 can be observed in the active site of the enzyme, identifying clearly the location of TPP+ moiety at the entrance of the active-site gorge of the enzyme (Figure 2, bottom left). Strong stacking interaction between aromatic amino...
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