Additionally, availability of tumor sequences represents a bottleneck in conservation and variability analyses, but this is likely to be remedied in a near future, as high-throughput sequencing becomes cheaper and more efficient. Another issue currently being addressed is that intra-tumor diversity may...
Precise location of the p53 binding site has been reported for 266 of the 399 gene-study pairs. In general, the number of p53 binding events decreases with increasing distance from the transcriptional start site (TSS). Proximal p53 binding—that is, within 1 kb from the TSS—occurs most ...
d Visualization of PTBP2 eCLIP-seq data from human cortex highlighting two highly enriched PTBP binding regions near SYN- GAP1 exon 11: site 1 (green, intronic site) and site 2 (blue, NMD-inducing Exon 11x). Zoom-ins for both sites are provided including information about the nucleotide ...
similar to so-called excitation-contraction coupling in skeletal muscle cells. Both ryanodine receptors and L-type Ca channels seem to be colocalized near the axolemma of myelinated axons. However, the blockage of intra-axonal calcium release, e.g. through the L-type calcium channel blocker ni...
uwlahricphh cootrorreescpeopntodr tsoo tnheth eextOenptt iocfa lthCeo phreerseenrcveedTo mmaocgurlaapr hpyho(OtoCreTc)espctaonrss o((nE )t:hrei gOhpt teiycael aCnodh(eFr)e:nlecfet Teoyme).ography (OCT) scans (E: right eye and...