Deep brain stimulation (DBS) is now well established in the treatment of intractable movement disorders. Over the past decade the clinical applications have expanded into the realm of psychosurgery, including depression and obsessive compulsive disorder (OCD). The optimal targets for electrode placement...
The fluorescence intensity of the QDs-OCD was highly accumulated in blood cells, while the unmodified QDs did not accumulate significantly in blood cells. Conclusion: The formulated novel QDs-OCD can target SSTR2 overexpressed in blood cells with great potential for treating blood...
From there, the research team used the atlas to develop an algorithm to generate symptom-specific, personalized DBS treatment plans. The tool, known as Cleartune, uses insights from the atlas to select optimal stimulation parameters in patients undergoing DBS. To test the algorithm...
“When typically putting someone on an SSRI in the postpartum, it is important to inform them, 'This medication may not take effect for four to 12 weeks. Additionally, if dealing with severe depression, it might be necessary to continue this treatment for at least six months to a ye...
Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for d... Preclinical Research Traditional pharmacological approaches to the treatment of obsessive鈥揷ompulsive disorder (OCD) are based on affecting serotonerg...
Neuromodulation trials for the treatment of posttraumatic stress disorder (PTSD) have yielded mixed results, and the optimal neuroanatomical target remains unclear. Here we analyzed three datasets to study brain circuitry causally linked to PTSD in military veterans. In veterans with penetrating traumatic...
Medical Center have uncovered a new genetic signature that correlates strongly with autism and which doesn't involve changes to the DNA sequence itself. Rather, the changes are in the way the genes are turned on and off. The finding may suggest new approaches to diagnosis and treatment of ...
For OCD treatment, theInternational OCD Foundationstates that stimulation in the anterior cingulate cortex is effective. “For individuals with dystonia, DBS may reduce the disorder’s characteristic involuntary muscle contractions that cause such symptoms as abnormal posture, repetitive movements, or twisti...
Intravenous immunoglobulin inhibits \\{BAFF\\} production in chronic inflammatory demyelinating polyneuropathy — A new mechanism of action? \\{BAFF\\} as a new target for \\{IVIg\\} in \\{CIDP\\} treatment and provide a new, Fc纬-receptor independent, mechanism of action for IVI... Sand...
obsessive–compulsive disorder (OCD)brain-derived neutrophic factor (BDNF)mammalian target of rapamycin (mTOR)FKBP12GRM5Preclinical ResearchTraditional pharmacological approaches to the treatment of obsessive鈥揷ompulsive disorder (OCD) are based on affecting serotonergic and dopaminergic transmission in the ...