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Role of SIRT1 and SIRT6 in chromatin condensation. SIRT1 and SIRT6 promote formation of heterochromatin in three ways. Firstly, both of the sirtuins deacetylate H3K9 enabling its trimethylation and subsequent binding of HP1α indispensable for heterochromatin formation. Secondly, SIRT1 decreases activ...
Houben AJ, Moolenaar WH . Autotaxin and LPA receptor signaling in cancer.Cancer Metastasis Rev2011;30: 557–565. ArticleCASPubMedGoogle Scholar Pyne NJ, Pyne S . Sphingosine 1-phosphate and cancer.Nat Rev Cancer2010;10: 489–503. ArticleCASPubMedGoogle Scholar Wang D, Dubois RN . Eicosanoids...
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federal law that specifies that, in the United States, the use of an electronic signature (e-signature) is as legally valid as a traditional signature written in ink on paper. Continue Reading By Alexander S. Gillis, Technical Writer and Editor Tip 16 Feb 2023 Web 3.0 security risks: ...
To investigate the presence of mid-old cells, we employed mid-old cell markers that were derived in vitro and quantified their expression through immunohistochemistry (IHC) in elderly tissues. Previous studies have shown that the proportion of p16INK4A-positive cells remains relatively low, even as...
Nothacker HP, Wang Z, Zhu Y, Reinscheid RK, Lin SH, Civelli O . Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol 2000; 58: 1601–1608. Article CAS PubMed Google Scholar Dong X, Zhao Y, Huang...
Biederbick A, Kern HF, Elsasser HP. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol. 1995;66:3–14. CAS PubMed Google Scholar Tanida I, Ueno T, Kominami E. LC3 and autophagy. Methods Mol Biol. 2008;445:77–88. CAS PubMed Google ...
et al. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by polycomb and HP1 chromodomains. Genes Dev. 17, 1870–1881 (2003). Article CAS PubMed PubMed Central Google Scholar Zhen, C. Y. et al. Live-cell single-molecule tracking reveals co-...