Thus, the stimulation of autophagy by targeting HDAC could be another candi- date therapeutic strategy; suberoylanilide hydroxamic acid (SAHA), a well known HDAC inhibitor, can trigger caspase- independent autophagic cell death in endometrial stromal sarcoma cells[83]. Recently, a new synthetic HDAC...
Autophagy is readily induced in response to nutrient deprivation, metabolic stress, endoplasmic reticulum (ER)-stress, radiation and anticancer drugs. In general, the complete autophagic process can be divided into several stages, including induction, vesicle nucleation, vesicle elongation and completion, ...
Therefore, in the presence of stimuli cable of enhancing autophagic responses, there is an increment in LC3 cellular levels while a correct completion of the process is characterized by its reduction [13,14]. LC3-II interacts with a class of autophagy adaptors known as sequestosome-1/p62-like ...
3.4. Mitotic Catastrophe Mitotic catastrophe has been characterized as the main form of cell death induced by ionizing irradiation [145] and results from premature induction of mitosis before completion of the S and G2 phase [146]. Inhibition or knockout of proteins that control the G2 ...