A 52-year-old African-American man had a mild anemia (hemoglobin of 103 g/L) and target cells on the peripheral blood smear as shown. The white blood cell and platelet counts were normal. The referring physician assumed that a hemoglobinopathy could be present and a hemoglobin electrophoresis...
Hereditary spherocytosis (HS) is the most common cause of hereditary hemolytic anemia (HHA) characterized by the presence of spherocytes in peripheral blood smear (PBS) [1, 2]. HS occurs in 1 in 2000 Caucasians, with less common frequency in Asians [1, 3, 4]. The crude incidence of HS...
Lymph nodes (LNs) are immunological organs that are strategically positioned at sites where antigens drain from peripheral tissues1. Once antigens are presented by antigen-presenting cells (APCs) residing in the tumor-draining LNs, an adaptive immune response is generated to defend against a tumor...
Cells were initially assembled on chips and characterized without the presence of thePlasmodium falciparumin the malaria-on-a-chip platform. This characterization was executed for a 7-day period and allowed for the determination of cell viability, function, and morphology in a healthy control system....
This topic clearly requires more attention and the performance of in vitro bridge studies using human peripheral blood-derived cells in addition to the usual in vivo animal studies and in vitro TCR studies to avoid potential issues caused by species differences. In conclusion, CH12 induces ...
Evidence of MAHA together with LEA changes on peripheral smear is virtually diagnostic of malignant disease with secondary deposits in the marrow and replacement of marrow by tumor cells may not be the sole cause of severe anemia, in contrast to that seen in acute leukemia.Mangala, G...
Correlation of peripheral smear with RBC indices and RBC histograms in the diagnosis of anemiaSandhya, VRashmi, G.S.B
Chronic myelogenous leukemia (CML) is a clonal myeloproliferation of pleuripotent stem cells, mainly granulocyte series. Diagnosis of CML is usually based on peripheral blood smear examination viz, normocytic normochromic anaemia, marked neutrophilia with a shift to left and vacuolation of cytoplasm...
cells. Once AML was established, these mice were treated with vehicle or 25 mg/kg SP2509 twice per week via i.p. injection. The mice were monitored by flow cytometry, CBC, and blood smear.e,fRepresentative flow plots showing the expression of Mac-1 in peripheral blood AML cells in ...
She had echymotic patches on trunk and arm, moderate hepato-splenomegaly, swollen cyanosed cold right forearm. Neonatal sepsis was suspected but sepsis screen was negative. Peripheral blood smear revealed marked leucocytosis with 70% myeloblast cells, thrombocytopenia and normal erythrocyte count. Bone...