tapinarof乳膏治疗斑块型银屑病 Tapinarof Cream for Plaque Psoriasis 2021年12月9日 朗读者:Dr. Stephen Morrissey,NEJM常务执行主编 斑块型银屑病的主要治疗方式是外用药,它们无法长期用药或所有皮肤部位用药。外用的tapinarof是在研的替代疗法。短视频...
与现有的银屑病治疗方法相比,需要进行更大规模、更长时间的试验来评估tapinarof乳膏的疗效和安全性。 参考文献:Lebwohl MG, Gold LS, Strober B, et al. Phase 3 trials of tapinarof cream for plaque psoriasis[J]. New England Journal of Medicine,2021,385:2219-2229....
原始出处: Mark G. Lebwohl,et al.Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis.NEJM.2021.https://www.nejm.org/doi/full/10.1056/NEJMoa2103629 撰文:xing.T 编辑:Niya 仅供医生学习和交流
与现有的银屑病治疗方法相比,需要进行更大规模、更长时间的试验来评估tapinarof乳膏的疗效和安全性。 参考文献:Lebwohl MG, Gold LS, Strober B, et al. Phase 3 trials of tapinarof cream for plaque psoriasis[J]. New England Journal of Medicine,2021,385:2219-2229. 推荐 世界医药里程碑系列①-茶...
参考来源:FDA Approves Dermavant’s Vtama® (tapinarof) cream, 1% for the treatment of plaque psoriasis in adults: first topical novel chemical entity launched for psoriasis in the U.S. in 25 years.新闻发布,Dermavant Sciences;2022年5月24日。2022年5月25日访问。
参考来源:FDA Approves Dermavant’s Vtama® (tapinarof) cream, 1% for the treatment of plaque psoriasis in adults: first topical novel chemical entity launched for psoriasis in the U.S. in 25 years.新闻发布,Dermavant Sciences;2022年5月24日。2022年5月25日访问。
参考来源:FDA Approves Dermavant’s Vtama® (tapinarof) cream, 1% for the treatment of plaque psoriasis in adults: first topical novel chemical entity launched for psoriasis in the U.S. in 25 years.新闻发布,Dermavant Sciences;2022年5月24日。2022年5月25日访问。
https://www.businesswire.com/news/home/20210810005299/en/Dermavant-Announces-FDA-Acceptance-for-Filing-of-New-Drug-Application-NDA-for-Tapinarof-Cream-for-the-Treatment-of-Adults-with-Plaque-Psoriasis haoeyou.com/pifuzhuankejibing/20210816/6605.html...
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease. 靶点活性 AhR:13 nM(EC50) 体外活性 Tapinarof activates the AhR pathway through direct binding. Tapinarof induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) ...
Tapinarof-mediated AhR signaling underlies the mechanistic basis for the significant efficacy and acceptable tolerability observed in early phase clinical trials of tapinarof cream in the treatment of psoriasis.doi:10.1016/j.jaad.2020.10.085Robert Bissonnette...