Meaning These findings suggest that opioid dose tapering was associated increased risks of overdose-withdrawal and mental health crisis that persisted up to 2 years after taper initiation. Abstract Importance Patients prescribed long-term opioid therapy are increasingly undergoing dose tapering. Recent studi...
Meaning A substantial percentage of patients prescribed long-term opioid therapy are undergoing tapering, often at rapid maximum rates. Abstract Importance A 2016 Centers for Disease Control and Prevention prescribing guideline cautioned against higher-dose long-term opioid therapy and recommended tapering...
Meaning Opioid dose tapering was associated with increased risk for overdose and mental health crisis, but interpretation of these findings is limited by the study design. Abstract Importance Opioid-related mortality and national prescribing guidelines have led to tapering of doses among patients prescrib...