Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type. Neurosci Lett 1993;162:176–178. View ArticleIkeda,K. et al.Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type. Neuroscience Letters . ...
The development of radioligands to image -amyloid (A) plaques and neurofibrillary tangles (NFTs) in vivo in the aging human brain is an important and active area of radiopharmaceutical design. When used in combination with positron emission tomography (PET) or single photon emission computed tomogra...
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“The mice were 20 months old and had advanced brain disease when we started the therapy,” says study senior author Miranda E. Orr, Ph.D., a pharmacologist at UT Health San Antonio. “After clearing the senescent cells, we saw improvements in brain structure and function. “The treatment...
The locus coeruleus belongs to brain areas exhibiting remarkable neuronal loss already during physiological aging and very early neurofibrillary tangles. We performed a semiquantitative, immunocytochemical study focused on the expression of ubiquitin in neurofibrillary tangles in the locus coeruleus as compared...
BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: implications for Alzheimer's disease therapeutics Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. The maj... SL...
This book shows a whole other side of how brains work by examining the most unusual behavior to emerge from the human brain. In it, you'll meet a woman who is afraid to take a shower because she fears her body will slip down the drain, a man who is convinced he is a cat, a wom...
, six developmental stages can be distinguished, reflecting the predictable manner in which the neurofibrillary changes spread through the telencephalic cortex. ... H Braak,RAID Vos,ENH Jansen,... - 《Progress in Brain Research》 被引量: 242发表: 1998年 Neuroimaging correlates of pathologically def...
The presence of Lewy body and neurofibrillary tangle in the locus ceruleus neurons of aged brain is described. Ultrastructural study revealed that in some Lewy bodies the presence of "twisted tubules" or "paired helical filaments" amongst the filaments of the Lewy body. A quantitative analysis of...