Sartorius hollow fiber tangential flow filtration (TFF) modules provide high-performance separation in various upstream and downstream bioprocessing unit operations, including cell harvest, clarification, perfusion, diafiltration and concentration Explore Hollow Fiber TFF ...
点击上方的 行舟Drug ▲ 添加关注 摘要:切向流过滤(Tangential Flow Filtration,TFF),即超滤,是一种已经被广泛采用的过滤操作方式,它的应用包括澄清过滤、产物浓缩、除热原、除小分子杂质、脱盐和缓冲液置换等等。本文将以超滤为切入点,详细介绍其在生物制药领域的广泛应用。 背景介绍 超滤或切向流过滤是一种介于微滤...
The present study used tangential flow filtration (TFF) to isolate polymeric Hp from plasma proteins using human Fraction IV (FIV) as the starting material. After removal of insoluble material from a suspension of FIV paste, the protein mixture was clarified on a 0.2 μm hollow fiber (HF) ...
Reasons to choose TFF instead ofnormal flow filtration (NFF)include: TFF prevents “filter cake” formation, for high liquid removal rates. Process feed stays as a mobile slurry that’s usable for further recirculation. The solid content of the product slurry is highly variable. ...
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Elevate Filtration Precision: Our tangential flow products ensure purity for mAbs, vaccines, and more, scaling from single-use to multi-use.
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solution properties of the drug substance (e.g. buffer composition and solution viscosity) to the operational set points of the experiment. Using the workflow, we can run a minimal number of experiments and use these results to simulate how the filtration will operate under a range of set ...
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