An anastrozole adjuvant trial was conducted in 9,366 postmenopausal women with operable breast cancer who were randomized to receive adjuvant treatment with either anastrozole 1 mg daily, tamoxifen 20 mg daily, or a combination of these two treatments for 5 years or until recurrence of the disease...
Tissue engineered vascular grafts hold promise for the creation of functional blood vessels from biodegradable scaffolds. Because the precise mechanisms regulating this process are still under investigation, inducible genetic mouse models are an importan
Tamoxifen is available in a tablet (10 mg or 20 mg) or an oral solution (10 mg/5 mL). If administered as an oral solution, it is important to use the supplied dosing cup for adequate administration. FDA-approved indication dosing is as follows: The American Society of Clinical Oncology ...
Thirty-four post-menopausal women with early breast cancer who had received 20 mg tamoxifen once daily as adjuvant therapy for at least 10 weeks participat... M Dowsett,JS Tobias,A Howell,... - 《British Journal of Cancer》 被引量: 131发表: 1999年 The influence of letrozole on serum ...
Risk-eligible women are ≥ 35 years of age and postmenopausal; they have either lobular carcinoma in situ (LCIS) or a 5-year risk of invasive breast cancer of at least 1.67% as determined by the Gail model. Participants are randomly assigned to receive either tamoxifen 20 mg or raloxifene ...
These benefits appeared to be largely irrespective of age, menopausal status, daily tamoxifen dose (which was generally 20 mg), and of whether chemotherapy had been given to both groups. In terms of other outcomes among all women studied (ie, including those with "ER-poor" tumours), the ...
Intervention Oral tamoxifen (20 mg/d) or raloxifene (60 mg/d) over 5 years. Main Outcome Measures Incidence of invasive breast cancer, uterine cancer, noninvasive breast cancer, bone fractures, thromboembolic events. Results There were 163 cases of invasive breast cancer in women assigned to tam...
20 or 35 mg/kg/day (69%) compared to those administered 5 mg/kg/day (14%). In a separate study, rats were administered tamoxifen at 45 mg/kg/day (about nine-fold the daily maximum recommended human dose on a mg/m² basis); hepatocellular neoplasia was exhibited at 3 to 6 months...
18.Nanofibers as a matrix for mini tabletsElectrospinningPVPPrednisoneNanofiber mat showed 100% drug release in 5 min whereas minitablet showed 100% drug release in 20 min[107] 19.Nanofibers for sublingual administrationElectrospinningPVP, PEGIsosorbide dinitrateAlmost 100% released after only 120 s[10...
Wistar albino rats were injected tamoxifen citrate intraperitoneally in three different doses (10 mg/kg and 20 mg/kg bw for 26 days; and 45 mg/kg bw for three days). Another group of animals were treated with melatonin once a week in addition to daily tamoxifen injections, whereas the ...