(lower alkyl)amino, and (lower alkanoyl)amino; Z is -O-, -S- or -N(R<4>)-; and R<4> and R<5> are independently selected from hydrogen or lower alkyl or (lower cycloalkyl) lower alkyl or are together -(CH2)n- wherein n is an integer from 3 to 5; R<2> is selected ...
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Brilliant Black PN consists essentially of tetrasodium-4-acetamido-5- hydroxy-6-[7-sulfonato-4-(4-sulfonatophenylazo)-1-naphthylazo] naphthalene-1,7-disulfonate and subsidiary colouring matters together with sodium chloride and/or sodium sulphate as the principal uncoloured components. EurLex-2 Li...
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or together R2 and R3 may form certain heterocyclic radicals; R4 is hydrogen, lower alkyl, aryl or certain heterocyclic radicals; R5 is lower alkyl, aryl or aralkyl and X is hydrogen, hydroxy, lower alkanoyloxy, aroyloxy, aralkanoyloxy, the radical of a nitrogen base, a quaternary ammonium...
In tab. 3 shows the yield of the target compound obtained at different pH values, together with the moisture content of the product. NMR data is identical to that shown in Example 1. Table 3 Example 18. The B-gram samples of the dihydrochloride prepared according to Example A were dissolve...
(lower alkyl)amino, and (lower alkanoyl)amino; Z is -O-, -S- or -N(R<4>)-; and R<4> and R<5> are independently selected from hydrogen or lower alkyl or (lower cycloalkyl) lower alkyl or are together -(CH2)n- wherein n is an integer from 3 to 5; R<2> is selected ...
(C 1 -C 4 )alkyl group, or else R 2 and R 3 , together with the nitrogen atom bearing them, form a pyrrolidinyl, piperidinyl, morpholinyl or 4-(C 1 -C 4 )alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl...
(C1-C6)alkoxy group; or R7 and R8, when adjacent to each other, taken together with the carbon atoms to which they are attached form a 5-8 membered carbocyclic or heterocyclic ring, wherein the carbocyclic ring or the heterocyclic ring is unsubstituted or substituted with one or more ...
Taken together, this study suggests that nilotinib may have higher anti-fibrotic activity when administered at a significant stage of fibrosis as a result of impairment of its metabolism in the fibrotic livers.doi:10.1016/j.ejphar.2011.08.041Mohamed E. Shaker...