Ascites is a sign of peritoneal metastases, creating a prometastatic microenvironment and heralding a poor prognosis [24, 25]. To further assess TAM polarization during peritoneal metastases, the TAM population was evaluated in the ascites of EOC patients (n = 10). Similar to the TAM polari...
This may arise from differential immune maturation processes in children and adults, but also from the inclusion of TNF-α-producing CD4 T cells in the phenotypic assessment of the TAM assay. The poor specificity of the CD27-based assay in adults may also rely on the observation reported by ...