On the other hand, in the microscopic world, nanometer-scale molecules must connect micrometer-scale structures that move at different speeds. Molecular stretching may be a fundamental mechanism for force transmission as exemplified by the elastic transient clutch of Talin....
Therefore, crucial functional and signaling differences must exist between the two closely related G proteins. In this context, it is known that Gα13 plays an important role in the regulation of RhoA activity in a variety of cells, notably through its SR1. In platelets, Gα13/RhoA activity...
24. As the folded talin rod has a contour length of only∼80 nm (ref.25), extension fluctuation over such a wide range indicates that some domains in the talin rod must be in unfolded states (Fig. 6a). An important question is...
D. Buggers must place as many items as they can in the bags.80. What is the article mainly about? A. The popularity of bagging contests in the West. B. How Tali a Randle discovered the fun of bagging. C. Glen Hasstedt's seciet training method for champion baggers. D. Tali a ...
To allow integrins to perform diverse roles with a high degree of spatial and temporal specificity, integrin-mediated adhesion must be modulated rapidly and precisely (Iwamoto and Calderwood, 2015, Wolfenson et al., 2013). One of the best-characterized methods of regulation is integrin activation....
Captain Kate has an iconic sphynx cat named Bug Naked which sails with her on the cruise ships that she takes command of. You may or may not have seen her YouTube, Instagram and TikTok accounts, but if you have not. It is a must see. ...
Our biochemical experiments indicate that domains flanking ABS2 suppress its activity (Fig. 4c), suggesting that talin must undergo a conformational change that relieves this inhibitory effect. Since the talinFLKVK/DDD mutation inhibits FA assembly (Fig. 7a), it seems likely that activation of ABS...
, 21.(17,21), that is, talin binding must be accompanied by other molecular binding (e.g., PIP2 [18](18)) to vinculin for full vinculin activation. In conclusion, a Vh1-VBS binding mechanism has been proposed that involves hydrophobic insertion of VBS1 into Vh1, separation of H1 and...
3), more subtle effects must account for the specificity. To address the above issues and to further define the specificity of vinculin binding, we performed a SPOT-peptide analysis substituting each of the commonly occurring amino acids into each of the 16 central positions of the VBS1 ...
1g) must be accompanied by the same decrease in THD1 affinity in the presence of KIND2. Because THD1 affinity, however, does not decrease in the presence of KIND2, we hypothesized that allostery in the β-CT and/or between talin and KIND2 caused by a direct talin–KIND2 interaction ...